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Focal Adhesion Network Components

The network contain 156 biomolecular components, including 25 adaptors, 24 cytoskeletal,10 serine/threonine kinases, 3 serine/threonine phosphatases, 9 actin binding proteins, 9 tyrosine phosphatases, 8 GAPs, 8 GEFs, 8 tyrosine kinases, 7 receptors, 6 adhesion proteins, 5 GTPase and 32 other types of components. 91 components are bona-fide focal adhesion components while 65 are considered focal adhesion associated.
NameTypeLocationLinksIn LinksOut LinksCCAvg. Path Length
ABI1AdapterFACA9100.3055562.45806
ABL1TyrKinaseFAC195100.2105262.11613
ACTBCytoskeletalFAC23120.07509882.19355
ACTN1ActinbundlingFAC18510.1045752.2
ADAM12MetalloproteinaseFACA6110.2666672.48387
AKT1SerThrKinaseFACA12570.3181822.23226
ARF1GTPaseFACA5310.32.68387
ARHGAP24GAPFAC20102.98065
ARHGAP26GAPFAC3010.3333332.69032
ARHGAP5GAPFACA10103.41935
ARHGEF6GEFFAC9120.2222222.36774
ARPC2ActinBindingFACA4010.3333332.85161
BCAR1CytoskeletalFAC21900.1952382.23226
BCAR3GEFFACA5030.32.64516
C20orf42CytoskeletalFAC10002.96129
CalciumMessengerFACA32102.97419
CALRChaperoneFAC20003.28387
CAPN1CysProteaseFACA214170.22.0129
CAV1CytoskeletalFAC14210.06593412.29677
CBLE3ligaseFACA26950.2584622.10323
CD47ReceptorFACA30002.89677
CEACAM1AdhesionFACA6000.1333332.52903
CFL1ActinBindingFACA43002.89032
CRKCytoskeletalFAC17000.1838242.29032
CRKLAdapterFAC12000.2121212.4
CSKTyrKinaseFAC11140.3090912.32258
CSRP1CytoskeletalFACA3000.6666672.89677
CTTNActinbindingFAC9400.1388892.33548
DAGLipidFACA21112.76774
DDEF1GAPFAC8310.3571432.32903
DDEF2GAPFAC3110.6666672.8
DMNAdapterFAC20003.16129
DNM2GTPaseFAC13100.1538462.32903
DOCK1GEFFAC4010.52.91613
ELMO1GEFFAC30113.0129
ENAHActinBindingFAC30003.13548
ENGAdhesionFACA20003.40645
FBLIM1CytoskeletalFAC30003.03226
FHL2AdapterFAC3000.6666672.66452
FLNAActinBindingFAC16500.1333332.19355
FYNTyrKinaseFACA233130.2094862.09032
GAB1AdaptorFAC8200.3571432.53548
GIT1GAPFAC11210.2363642.25806
GNB2L1AdapterFAC6010.62.4129
GRB2AdapterFAC26100.2369232.16774
GRB7AdapterFAC3100.6666672.69032
HRASGTPaseFACA6320.2666672.76129
HSPA2ChaperoneFACA20012.65806
HSPB1ChaperoneFACA20002.9871
ILKSerThrKinaseFAC9210.1111112.49032
ILKAPSerThrPhosphataseFACA10003.48387
INPP5DPtdInsPhosphataseFAC8010.2857142.64516
INPPL1PtdInsPhosphataseFAC7110.2380952.47742
INSRReceptorFACA183100.2156862.25161
IP3LipidFACA21103.11613
IRS1AdapterFACA11700.3454552.36129
ITGA5AdhesionFAC13110.06410262.40645
ITGB1AdhesionFAC31700.1333331.96774
ITGB3BPTFFAC10002.96129
JUBCytoskeletalFAC20003.02581
KALPHA1CytoskeletalFACA7100.5714292.51613
KCNH2ChannelFACA3000.3333332.65161
KEAP1ActinBundlingFAC10003.1871
KTN1ReceptorFAC22003.12903
LASP1ActinBindingFAC7200.2857142.65806
LAYNReceptorFACA20003.09677
LIMK1SerThrKinaseFACA32103.08387
LIMS1AdapterFAC20003.20645
LPPAdapterFAC3000.3333333.03871
LPXNAdapterFAC4000.52.70968
LRP1ReceptorFAC3100.3333332.78065
LYNTyrKinaseFACA13150.3846152.28387
MAPK1SerThrKinaseFACA8060.252.38065
MAPK8SerThrKinaseFACA5030.12.72903
MAPK8IP3AdapterFACA4100.52.56774
MARCKSActinBundlingFACA22012.74839
NCK2AdapterFAC9000.1944442.45806
NEDD9CytoskeletalFAC11300.2363642.41935
NEXNActinBindingFAC10003.1871
NF2CytoskeletalFAC50102.56129
NUDT16L1AdapterFAC30002.7871
OSTF1AdapterFAC21012.77419
p190GAPNANA6310.42.37419
P190GAPNANA21102.87097
PABPC1RNAMetabolismFACA10002.94194
PAK1SerThrKinaseFAC19840.09941522.2
PALLDCytoskeletalFAC6000.22.87097
PARVACytoskeletalFAC4010.1666672.59355
PARVBCytoskeletalFAC30002.89032
PDPK1SerThrKinaseFAC6140.62.38065
PFN1ActinBindingFACA6100.1333332.78065
PIK3CAPtdInsKinaseFACA22540.2424242.19355
PIP2LipidFACA132110.1153852.45806
PIP3LipidFACA8440.1071432.52903
PIP5K1CPtdInsKinaseFACA7310.2380952.43871
PKD1ChannelFAC5100.42.54839
PLAURReceptorFACA30002.83871
PLCG1PtdInsKinaseFAC19620.2982462.16129
PLD1PhospholipaseFACA9710.2222222.37419
PLEC1CytoskeletalFACA30002.72903
PLEKHC1CytoskeletalFAC10004.02581
PPFIA1AdapterFAC20003.1871
PPM1MSerThrPhosphataseFAC20113.04516
PPP2CASerThrPhosphataseFAC9170.1666672.28387
PRKACASerThrKinaseFACA9090.2777782.34194
PRKCASerThrKinaseFAC3611230.1428571.87742
PTENPtdInsPhosphataseFACA5130.12.56774
PTK2TyrKinaseFAC42770.1358891.86452
PTK2BTyrKinaseFAC24360.2717392.10323
PTPN1TyrPhosphataseFACA10450.2444442.26452
PTPN11TyrPhosphataseFAC14370.329672.26452
PTPN12TyrPhosphataseFAC15270.22.24516
PTPN2TyrPhosphataseFACA4130.3333332.69677
PTPN6TyrPhosphataseFAC15650.2476192.23871
PTPRATyrPhosphataseFAC6230.62.45161
PTPRFTyrPhosphataseFAC5130.12.77419
PTPRHTyrPhosphataseFACA30312.58065
PTPROTyrPhosphataseFACA10102.94194
PXNAdapterFAC361100.1047621.94839
RAC1GTPaseFACA211260.08571432.27097
RAPGEF1GEFFACA6100.62.63226
RASA1GAPFAC7210.3333332.46452
RAVER1RNAMetabolismFAC20012.9871
RHOAGTPaseFACA15870.07619052.42581
RICSGAPFACA8220.2142862.52903
ROCK1SerThrKinaseFACA61402.79355
SDC4AdhesionFAC9300.1388892.47097
SDCBPCytoskeletalFAC3100.3333333.09032
SH3KBP1AdapterFAC9100.4444442.51613
SHC1AdapterFACA24700.2644932.12903
SIRPAReceptorFACA4200.1666672.90968
SLC9A1ExchangerFACA10003.25806
SORBS1AdapterFACA9000.2777782.39355
SORBS2AdapterFAC6100.3333332.6
SORBS3CytoskeletalFAC5100.32.60645
SOS1RasGEFFACA13120.1153852.49677
SRCTyrKinaseFAC4510320.1242421.92258
STAT3TFFAC7600.2857142.42581
SYKTyrKinaseFACA196100.3976612.10323
TESAdapterFAC4000.3333332.95484
TESK1DualKinaseFACA32103.06452
TGFB1I1AdapterFAC9200.2222222.49677
THY1AdhesionFACA5000.62.47742
TIAM1GEFFACA6410.1333332.43226
TLN1CytoskeletalFAC13300.1923082.25161
TNS1CytoskeletalFAC4100.1666672.56129
TRIOGEFFACA5020.12.50323
TRIP6AdapterFAC5100.22.62581
TRPM7ChannelFAC10103.96774
TSPAN1AdapterFACA3000.3333332.66452
VASPActinBindingFAC13300.1538462.45161
VAV1GEFFACA18730.274512.23871
VCLCytoskeletalFAC15300.1619052.25161
VIL2CytoskeletalFAC13500.1282052.26452
VIMCytoskeletalFACA53002.68387
ZYXCytoskeletalFAC9000.1111112.67097