Focal Adhesion Network Components

VAV1

Swiss-Prot Human Accession Code: P15498
List of interactions:

Source:CBLType of molecule:E3ligase Location:FACA
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. A. M. Teckchandani, E. A. Feshchenko, A. Y. Tsygankov, Oncogene. 20, 1739 (2001). PubMed ID: 11313921

Source:CRKType of molecule:Cytoskeletal Location:FAC
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. L. Smit, d. e. r. van, G. Horst, et al., J. Biol. Chem. 271, 8564 (1996). PubMed ID: 8621483

Source:DNM2Type of molecule:GTPase Location:FAC
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. T. S. Gomez, M. J. Hamann, S. McCarney, et al., Nat. Immunol. 6, 261 (2005). PubMed ID: 15696170

Source:MAPK1Type of molecule:SerThrKinase Location:FACA
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. I. S. Lee, Y. Liu, M. Narazaki, et al., FEBS. Lett. 401, 133 (1997). PubMed ID: 9013873

Source:FYNType of molecule:TyrKinase Location:FACA
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. F. Michel, L. Grimaud, L. Tuosto, et al., J. Biol. Chem. 273, 31932 (1998). PubMed ID: 9822663

Source:GRB2Type of molecule:Adapter Location:FAC
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. I. S. Lee, Y. Liu, M. Narazaki, et al., FEBS. Lett. 401, 133 (1997). PubMed ID: 9013873

Source:INSRType of molecule:Receptor Location:FACA
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. Uddin, S. Katzav, M. F. White, et al., J. Biol. Chem. 270, 7712 (1995). PubMed ID: 7535775

Source:PIK3CAType of molecule:PtdInsKinase Location:FACA
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. V. Bertagnolo, M. Marchisio, S. Volinia, et al., FEBS. Lett. 441, 480 (1999). PubMed ID: 9891995

Source:PLCG1Type of molecule:PtdInsKinase Location:FAC
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. C. Pearce, O. J. McCarty, S. D. Calaminus, et al., Biochem. J. 401, 753 (2007). PubMed ID: 17054426

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. S. K. Sastry, Z. Rajfur, B. P. Liu, et al., J. Biol. Chem. 281, 11627 (2006). PubMed ID: 16513648

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. T. Katagiri, T. Takahashi, T. Sasaki, et al., J. Biol. Chem. 275, 19645 (2000). PubMed ID: 10867021

Source:SHC1Type of molecule:Adapter Location:FACA
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. L. Zeng, P. Sachdev, L. Yan, et al., Mol. Cell. Biol. 20, 9212 (2000). PubMed ID: 11094073

Source:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. M. Kon-Kozlowski, G. Pani, T. Pawson, et al., J. Biol. Chem. 271, 3856 (1996). PubMed ID: 8632004

Source:SYKType of molecule:TyrKinase Location:FACA
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. M. Deckert, S. Tartare-Deckert, C. Couture, et al., Immunity. 5, 591 (1997). PubMed ID: 8986718

Source:VAV1Type of molecule:GEF Location:FACA
Target:HRASType of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. E. Gulbins, K. M. Coggeshall, C. Langlet, et al., Mol. Cell. Biol. 14, 906 (1994). PubMed ID: 8289830

Source:VAV1Type of molecule:GEF Location:FACA
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. D. Fischer, Y. Y. Kong, H. Nishina, et al., Curr. Biol. 8, 554 (1998). PubMed ID: 9601639

Source:VAV1Type of molecule:GEF Location:FACA
Target:RHOAType of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. D. Fischer, Y. Y. Kong, H. Nishina, et al., Curr. Biol. 8, 554 (1998). PubMed ID: 9601639

Source:VAV1Type of molecule:GEF Location:FACA
Target:ZYXType of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. O. Hobert, J. W. Schilling, M. C. Beckerle, et al., Oncogene. 12, 1577 (1996). PubMed ID: 8622875