Focal Adhesion Network Components

TIAM1

Swiss-Prot Human Accession Code: Q13009
List of interactions:

Source:ARPC2Type of molecule:ActinBinding Location:FACA
Target:TIAM1Type of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. et al., Biochem. J. 397, 39 (2006). PubMed ID: 16599904

Source:HRASType of molecule:GTPase Location:FACA
Target:TIAM1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. J. Yamauchi, Y. Miyamoto, A. Tanoue, et al., Proc. Natl. Acad. Sci. U. S. A. 102, 14889 (2005). PubMed ID: 16203995

Source:PIP2Type of molecule:Lipid Location:FACA
Target:TIAM1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. I. N. Fleming, I. H. Batty, A. R. Prescott, et al., Biochem. J. 382, 857 (2004). PubMed ID: 15242348

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:TIAM1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. F. G. Buchanan, C. M. Elliot, M. Gibbs, et al., J. Biol. Chem. 275, 9742 (2000). PubMed ID: 10734127

Source:SRCType of molecule:TyrKinase Location:FAC
Target:TIAM1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. J. M. Servitja, M. J. Marinissen, A. Sodhi, et al., J. Biol. Chem. 278, 34339 (2003). PubMed ID: 12810717

Source:TIAM1Type of molecule:GEF Location:FACA
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. F. Michiels, G. G. Habets, J. C. Stam, et al., Nature. 375, 338 (1995). PubMed ID: 7753201