Focal Adhesion Network Components

SYK

Swiss-Prot Human Accession Code: P43405
List of interactions:

Source:CBLType of molecule:E3ligase Location:FACA
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. G. Panchamoorthy, T. Fukazawa, S. Miyake, et al., J. Biol. Chem. 271, 3187 (1996). PubMed ID: 8621719

Source:CRKLType of molecule:Adapter Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Oda, H. D. Ochs, L. A. Lasky, et al., Blood. 97, 2633 (2001). PubMed ID: 11313252

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. K. Sada, Y. Minami, H. Yamamura, Eur. J. Biochem. 248, 827 (1997). PubMed ID: 9342235

Source:GRB2Type of molecule:Adapter Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Saci, W. Q. Liu, M. Vidal, et al., Biochem. J. 363, 717 (2002). PubMed ID: 11964172

Source:ITGB1Type of molecule:Adhesion Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. S. Sarkar, M. M. Rooney, S. T. Lord, Biochem. J. 338, 677 (1999). PubMed ID: 10051438

Source:LYNType of molecule:TyrKinase Location:FACA
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. P. Sidorenko, C. L. Law, K. A. Chandran, et al., Proc. Natl. Acad. Sci. U. S. A. 92, 359 (1995). PubMed ID: 7831290

Source:PIK3CAType of molecule:PtdInsKinase Location:FACA
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. et al., Cell. Signal. 10, 407 (1998). PubMed ID: 9720763

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. P. Borowski, M. Heiland, L. Kornetzky, et al., Biochem. J. 331, 649 (1998). PubMed ID: 9531509

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. R. K. Ganju, S. A. Brubaker, R. D. Chernock, et al., J. Biol. Chem. 275, 17263 (2000). PubMed ID: 10747947

Source:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. J. Brockdorff, S. Williams, C. Couture, et al., Eur. J. Immunol. 29, 2539 (1999). PubMed ID: 10458769

Source:SRCType of molecule:TyrKinase Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. T. Kurosaki, M. Takata, Y. Yamanashi, et al., J. Exp. Med. 179, 1725 (1994). PubMed ID: 7513017

Source:SYKType of molecule:TyrKinase Location:FACA
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Activation Effect:+
References:
1. M. L. Lupher, R. a. o. Jr,, et al., J. Biol. Chem. 273, 35273 (1999). PubMed ID: 9857068

Source:SYKType of molecule:TyrKinase Location:FACA
Target:CTTNType of molecule:Actinbinding Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. Maruyama, T. Kurosaki, K. Sada, et al., J. Biol. Chem. 271, 6631 (1996). PubMed ID: 8636079

Source:SYKType of molecule:TyrKinase Location:FACA
Target:VIL2Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. A. Urzainqui, J. M. Serrador, F. Viedma, et al., Immunity. 17, 401 (2002). PubMed ID: 12387735

Source:SYKType of molecule:TyrKinase Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. R. Fernandez, S. J. Suchard, J. Immunol. 160, 5154 (1998). PubMed ID: 9590268

Source:SYKType of molecule:TyrKinase Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. G. Pula, D. Crosby, J. Baker, et al., J. Biol. Chem. 280, 7194 (2005). PubMed ID: 15583006

Source:SYKType of molecule:TyrKinase Location:FACA
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. L. Law, K. A. Chandran, S. P. Sidorenko, et al., Mol. Cell. Biol. 16, 1305 (1996). PubMed ID: 8657103

Source:SYKType of molecule:TyrKinase Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. Nagai, M. Takata, H. Yamamura, et al., J. Biol. Chem. 270, 6824 (1995). PubMed ID: 7896829

Source:SYKType of molecule:TyrKinase Location:FACA
Target:STAT3Type of molecule:TF Location:FAC
Type of interaction:Activation Effect:+
References:
1. L. Su, M. David, J. Biol. Chem. 275, 12661 (2000). PubMed ID: 10777558

Source:SYKType of molecule:TyrKinase Location:FACA
Target:KALPHA1Type of molecule:Cytoskeletal Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. Faruki, R. L. Geahlen, D. J. Asai, J. Cell. Sci. 113, 2557 (2000). PubMed ID: 10862713

Source:SYKType of molecule:TyrKinase Location:FACA
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. M. Deckert, S. Tartare-Deckert, C. Couture, et al., Immunity. 5, 591 (1997). PubMed ID: 8986718