Focal Adhesion Network Components

SRC

Swiss-Prot Human Accession Code: P12931
List of interactions:

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. A. Oda, B. J. Druker, H. Ariyoshi, et al., J. Biol. Chem. 268, 12603 (1993). PubMed ID: 7685344

Source:CBLType of molecule:E3ligase Location:FACA
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. H. Odai, K. Sasaki, Y. Hanazono, et al., Jpn. J. Cancer. Res. 86, 1119 (1996). PubMed ID: 8635998

Source:CSKType of molecule:TyrKinase Location:FAC
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. G. Superti-Furga, S. Fumagalli, M. Koegl, et al., EMBO. J. 12, 2625 (1993). PubMed ID: 7687537

Source:LPXNType of molecule:Adapter Location:FAC
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. N. Sahu, M. A. Khadeer, B. W. Robertson, et al., Am. J. Physiol. Cell. Physiol. 292, C581 (2007). PubMed ID: 16914530

Source:PRKACAType of molecule:SerThrKinase Location:FACA
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. P. Yaciuk, J. K. Choi, D. Shalloway, Mol. Cell. Biol. 9, 2453 (1989). PubMed ID: 2474754

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. K. L. Gould, J. R. Woodgett, J. A. Cooper, et al., Cell. 42, 849 (1985). PubMed ID: 2996780

Source:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. C. J. Pallen, D. S. Lai, H. P. Chia, et al., Biochem. J. 276, 315 (1991). PubMed ID: 1646596

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Jeschke, G. J. Standke, M. Scaronuscarona, J. Biol. Chem. 273, 11354 (1998). PubMed ID: 9556630

Source:GNB2L1Type of molecule:Adapter Location:FAC
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. B. Y. Chang, K. B. Conroy, E. M. Machleder, et al., Mol. Cell. Biol. 18, 3245 (1998). PubMed ID: 9584165

Source:PTPRAType of molecule:TyrPhosphatase Location:FAC
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. et al., EMBO. J. 12, 3789 (1993). PubMed ID: 7691597

Source:PTPRHType of molecule:TyrPhosphatase Location:FACA
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. S. Walchli, X. Espanel, Biochem. Biophys. Res. Commun. 331, 497 (2005). PubMed ID: 15850787

Source:INPP5DType of molecule:PtdInsPhosphatase Location:FAC
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. Giuriato, S. Bodin, C. Erneux, et al., Biochem. J. 348, 107 (2000). PubMed ID: 10794720

Source:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. A. K. Somani, J. S. Bignon, G. B. Mills, et al., J. Biol. Chem. 272, 21113 (1997). PubMed ID: 9261115

Source:SRCType of molecule:TyrKinase Location:FAC
Target:ABL1Type of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. R. Plattner, L. Kadlec, K. A. DeMali, et al., Genes. Dev. 13, 2400 (1999). PubMed ID: 10500097

Source:SRCType of molecule:TyrKinase Location:FAC
Target:ADAM12Type of molecule:Metalloproteinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. A. Suzuki, N. Kadota, T. Hara, et al., Oncogene. 19, 5842 (2000). PubMed ID: 11127814

Source:SRCType of molecule:TyrKinase Location:FAC
Target:AKT1Type of molecule:SerThrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. T. Jiang, Y. Qiu, J. Biol. Chem. 278, 15789 (2003). PubMed ID: 12600984

Source:SRCType of molecule:TyrKinase Location:FAC
Target:DDEF1Type of molecule:GAP Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. T. Brown, J. Andrade, H. Radhakrishna, et al., Mol. Cell. Biol. 18, 7038 (1998). PubMed ID: 9819391

Source:SRCType of molecule:TyrKinase Location:FAC
Target:RAPGEF1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. V. Radha, A. Rajanna, G. Swarup, BMC. Cell. Biol. 5, 31, (2004). PubMed ID: 15320955

Source:SRCType of molecule:TyrKinase Location:FAC
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. G. S. Goldberg, D. B. Alexander, P. Pellicena, et al., J. Biol. Chem. 278, 46533 (2003). PubMed ID: 12972425

Source:SRCType of molecule:TyrKinase Location:FAC
Target:CAV1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. Li, J. Couet, M. P. Lisanti, J. Biol. Chem. 271, 29182 (1997). PubMed ID: 8910575

Source:SRCType of molecule:TyrKinase Location:FAC
Target:CTTNType of molecule:Actinbinding Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. Huang, J. Liu, C. C. Haudenschild, et al., J. Biol. Chem. 273, 25770 (1998). PubMed ID: 9748248

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. B. Calalb, T. R. Polte, S. K. Hanks, Mol. Cell. Biol. 15, 954 (1995). PubMed ID: 7529876

Source:SRCType of molecule:TyrKinase Location:FAC
Target:GIT1Type of molecule:GAP Location:FAC
Type of interaction:Activation Effect:+
References:
1. J. Haendeler, G. Yin, Y. Hojo, et al., J. Biol. Chem. 278, 49936 (2003). PubMed ID: 14523024

Source:SRCType of molecule:TyrKinase Location:FAC
Target:GRB2Type of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. D. A. Jones, C. W. Benjamin, Arch. Biochem. Biophys. 337, 143 (1997). PubMed ID: 9016807

Source:SRCType of molecule:TyrKinase Location:FAC
Target:ITGB1Type of molecule:Adhesion Location:FAC
Type of interaction:Activation Effect:+
References:
1. A. Datta, F. Huber, D. Boettiger, J. Biol. Chem. 277, 3943 (2002). PubMed ID: 11723131

Source:SRCType of molecule:TyrKinase Location:FAC
Target:MAPK8IP3Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. T. Takino, K. Yoshioka, H. Miyamori, et al., Oncogene. 21, 6488 (2002). PubMed ID: 12226752

Source:SRCType of molecule:TyrKinase Location:FAC
Target:LRP1Type of molecule:Receptor Location:FAC
Type of interaction:Activation Effect:+
References:
1. H. Barnes, E. J. Ackermann, d. e. r. van, et al., Oncogene. 22, 3589 (2003). PubMed ID: 12789267

Source:SRCType of molecule:TyrKinase Location:FAC
Target:RASA1Type of molecule:GAP Location:FAC
Type of interaction:Activation Effect:+
References:
1. B. K. Brott, S. Decker, M. C. O'Brien, et al., Mol. Cell. Biol. 11, 5059 (1991). PubMed ID: 1717825

Source:SRCType of molecule:TyrKinase Location:FAC
Target:p190GAPType of molecule:NA Location:NA
Type of interaction:Activation Effect:+
References:
1. S. Zrihan-Licht, Y. Fu, J. Settleman, et al., Oncogene. 19, 1318 (2000). PubMed ID: 10713673

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. J. R. Glenney, J. Cell. Biol. 108, 2401 (1989). PubMed ID: 2472406

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PDPK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. Y. Taniyama, D. S. Weber, P. Rocic, et al., Mol. Cell. Biol. 23, 8019 (2003). PubMed ID: 14585963

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. A. Arcaro, M. Aubert, D. e. l. Espinosa, et al., Cell. Signal. (2007). PubMed ID: 17275257

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PIP5K1CType of molecule:PtdInsKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. et al., J. Biol. Chem. 280, 8381 (2005). PubMed ID: 15623515

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. L. Seibenhener, J. Roehm, W. O. White, et al., Mol. Cell. Biol. Res. Commun. 2, 28 (2000). PubMed ID: 10527887

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PKD1Type of molecule:Channel Location:FAC
Type of interaction:Activation Effect:+
References:
1. L. Geng, C. R. Burrow, H. P. Li, et al., Biochim. Biophys. Acta. 1535, 21 (2001). PubMed ID: 11113628

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. F. Liao, H. S. Shin, S. G. Rhee, Biochem. Biophys. Res. Commun. 191, 1028 (1993). PubMed ID: 7682059

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PTPRAType of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. EMBO. J. 13, 3020 (1994). PubMed ID: 7518772

Source:SRCType of molecule:TyrKinase Location:FAC
Target:RICSType of molecule:GAP Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. Y. Moon, H. Zang, Y. Zheng, J. Biol. Chem. 278, 4151 (2003). PubMed ID: 12454018

Source:SRCType of molecule:TyrKinase Location:FAC
Target:OSTF1Type of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. I. Szymkiewicz, O. Destaing, P. Jurdic, et al., FEBS. Lett. 565, 33 (2004). PubMed ID: 15135048

Source:SRCType of molecule:TyrKinase Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. J. McGlade, A. Cheng, G. Pelicci, et al., Proc. Natl. Acad. Sci. U. S. A. 89, 8869 (1992). PubMed ID: 1409579

Source:SRCType of molecule:TyrKinase Location:FAC
Target:INPPL1Type of molecule:PtdInsPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. N. Prasad, R. S. Topping, S. J. Decker, J. Cell. Sci. 115, 3807 (2002). PubMed ID: 12235291

Source:SRCType of molecule:TyrKinase Location:FAC
Target:STAT3Type of molecule:TF Location:FAC
Type of interaction:Activation Effect:+
References:
1. X. Cao, A. Tay, G. R. Guy, et al., Mol. Cell. Biol. 16, 1595 (1996). PubMed ID: 8657134

Source:SRCType of molecule:TyrKinase Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. T. Kurosaki, M. Takata, Y. Yamanashi, et al., J. Exp. Med. 179, 1725 (1994). PubMed ID: 7513017

Source:SRCType of molecule:TyrKinase Location:FAC
Target:TIAM1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. J. M. Servitja, M. J. Marinissen, A. Sodhi, et al., J. Biol. Chem. 278, 34339 (2003). PubMed ID: 12810717

Source:SRCType of molecule:TyrKinase Location:FAC
Target:TRIP6Type of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. Y. J. Lai, C. S. Chen, W. C. Lin, et al., Mol. Cell. Biol. 25, 5859 (2005). PubMed ID: 15988003

Source:PTPN2Type of molecule:TyrPhosphatase Location:FACA
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. et al., Nat. Immunol. 6, 253 (2005). PubMed ID: 15696169

Source:THY1Type of molecule:Adhesion Location:FACA
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. T. A. Rege, M. A. Pallero, C. Gomez, et al., Exp. Cell. Res. 312, 3752 (2006). PubMed ID: 17027000