Focal Adhesion Network Components

SOS1

Swiss-Prot Human Accession Code: Q07889
List of interactions:

Source:ABI1Type of molecule:Adapter Location:FACA
Target:SOS1Type of molecule:RasGEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. P. D. Fan, S. P. Goff, Mol. Cell. Biol. 20, 7591 (2000). PubMed ID: 11003655

Source:SH3KBP1Type of molecule:Adapter Location:FAC
Target:SOS1Type of molecule:RasGEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. S. Watanabe, H. Take, K. Takeda, et al., Biochem. Biophys. Res. Commun. 278, 167 (2000). PubMed ID: 11071869

Source:CRKType of molecule:Cytoskeletal Location:FAC
Target:SOS1Type of molecule:RasGEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. S. Okada, J. E. Pessin, J. Biol. Chem. 271, 25533 (1996). PubMed ID: 8810325

Source:CRKLType of molecule:Adapter Location:FAC
Target:SOS1Type of molecule:RasGEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. M. Sattler, R. Salgia, G. Shrikhande, et al., J. Biol. Chem. 272, 14320 (1997). PubMed ID: 9162067

Source:MAPK1Type of molecule:SerThrKinase Location:FACA
Target:SOS1Type of molecule:RasGEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. B. Waters, K. H. Holt, et al., J. Biol. Chem. 271, 6328 (1996). PubMed ID: 8626428

Source:FYNType of molecule:TyrKinase Location:FACA
Target:SOS1Type of molecule:RasGEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. C. Park, Y. Choi, Y. Yun, Mol. Cells. 8, 518 (1999). PubMed ID: 9856337

Source:GRB2Type of molecule:Adapter Location:FAC
Target:SOS1Type of molecule:RasGEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. P. Chardin, J. H. Camonis, N. W. Gale, et al., Science. 260, 1338 (1993). PubMed ID: 8493579

Source:NCK2Type of molecule:Adapter Location:FAC
Target:SOS1Type of molecule:RasGEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. L. E. Braverman, L. A. Quilliam, J. Biol. Chem. 274, 5542 (1999). PubMed ID: 10026169

Source:PLCG1Type of molecule:PtdInsKinase Location:FAC
Target:SOS1Type of molecule:RasGEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. M. J. Kim, J. S. Chang, S. K. Park, et al., Biochemistry. 39, 8674 (2000). PubMed ID: 10913276

Source:SORBS1Type of molecule:Adapter Location:FACA
Target:SOS1Type of molecule:RasGEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Kurakin, N. G. Hoffman, B. K. Kay, J. Pept. Res. 52, 331 (1999). PubMed ID: 9894838

Source:SOS1Type of molecule:RasGEF Location:FACA
Target:HRASType of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. P. A. Boriack-Sjodin, S. M. Margarit, D. Bar-Sagi, et al., Nature. 394, 337 (1998). PubMed ID: 9690470

Source:SOS1Type of molecule:RasGEF Location:FACA
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. A. S. Nimnual, B. A. Yatsula, D. Bar-Sagi, Science. 279, 560 (1998). PubMed ID: 9438849

Source:SOS1Type of molecule:RasGEF Location:FACA
Target:SORBS3Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Akamatsu, S. Aota, A. Suwa, et al., J. Biol. Chem. 274, 35933 (2000). PubMed ID: 10585480