Focal Adhesion Network Components

SHC1

Swiss-Prot Human Accession Code: P29353
List of interactions:

Source:RAPGEF1Type of molecule:GEF Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. L. Smit, d. e. r. van, G. Horst, et al., J. Biol. Chem. 271, 8564 (1996). PubMed ID: 8621483

Source:CBLType of molecule:E3ligase Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. G. Panchamoorthy, T. Fukazawa, S. Miyake, et al., J. Biol. Chem. 271, 3187 (1996). PubMed ID: 8621719

Source:CEACAM1Type of molecule:Adhesion Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. M. N. Poy, R. J. Ruch, M. A. Fernstrom, et al., J. Biol. Chem. 277, 1076 (2002). PubMed ID: 11694516

Source:CRKType of molecule:Cytoskeletal Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. M. Matsuda, S. Ota, R. Tanimura, et al., J. Biol. Chem. 271, 14468 (1996). PubMed ID: 8662907

Source:CRKLType of molecule:Adapter Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. H. Chin, T. Saito, A. Arai, et al., Biochem. Biophys. Res. Commun. 239, 412 (1997). PubMed ID: 9344843

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. D. D. Schlaepfer, K. C. Jones, T. Hunter, Mol. Cell. Biol. 18, 2571 (1998). PubMed ID: 9566877

Source:FYNType of molecule:TyrKinase Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. K. Wary, A. Mariotti, C. Zurzolo, et al., Cell. 94, 625 (1998). PubMed ID: 9741627

Source:GRB2Type of molecule:Adapter Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. E. Y. Skolnik, C. H. Lee, A. Batzer, et al., EMBO. J. 12, 1929 (1993). PubMed ID: 8491186

Source:ITGB1Type of molecule:Adhesion Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. K. J. Cowan, D. A. Law, D. R. Phillips, J. Biol. Chem. 275, 36423 (2000). PubMed ID: 10964917

Source:INSRType of molecule:Receptor Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. S. Kovacina, R. A. Roth, Biochem. Biophys. Res. Commun. 192, 1303 (1993). PubMed ID: 7685165

Source:IRS1Type of molecule:Adapter Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Kasus-Jacobi, D. Perdereau, S. Tartare-Deckert, et al., J. Biol. Chem. 272, 17166 (1997). PubMed ID: 9202037

Source:LRP1Type of molecule:Receptor Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. H. Barnes, B. Larsen, M. Tyers, et al., J. Biol. Chem. 276, 19119 (2001). PubMed ID: 11259429

Source:LYNType of molecule:TyrKinase Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Ptasznik, A. Traynor-Kaplan, G. M. Bokoch, J. Biol. Chem. 270, 19969 (1995). PubMed ID: 7650013

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Faisal, M. el-Shemerly, D. Hess, et al., J. Biol. Chem. 277, 30144 (2002). PubMed ID: 12052829

Source:PLCG1Type of molecule:PtdInsKinase Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. N. Perskvist, L. Zheng, O. Stendahl, J. Immunol. 164, 959 (2000). PubMed ID: 10623845

Source:PTENType of molecule:PtdInsPhosphatase Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. J. Gu, M. Tamura, R. Pankov, et al., J. Cell. Biol. 146, 389 (1999). PubMed ID: 10427092

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. T. Habib, R. Herrera, S. J. Decker, J. Biol. Chem. 269, 25243 (1994). PubMed ID: 7929214

Source:SHC1Type of molecule:Adapter Location:FACA
Target:INPP5DType of molecule:PtdInsPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. L. Liu, J. E. Damen, M. D. Ware, et al., J. Biol. Chem. 272, 10998 (1997). PubMed ID: 9110989

Source:SHC1Type of molecule:Adapter Location:FACA
Target:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. L. Delahaye, S. Rocchi, Endocrinology. 141, 621 (2000). PubMed ID: 10650943

Source:SHC1Type of molecule:Adapter Location:FACA
Target:SIRPAType of molecule:Receptor Location:FACA
Type of interaction:Binding Effect:0
References:
1. Y. Ling, L. A. Maile, J. Lieskovska, et al., Mol. Biol. Cell. 16, 3353 (2005). PubMed ID: 15888547

Source:SHC1Type of molecule:Adapter Location:FACA
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. L. Zeng, P. Sachdev, L. Yan, et al., Mol. Cell. Biol. 20, 9212 (2000). PubMed ID: 11094073

Source:SRCType of molecule:TyrKinase Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. J. McGlade, A. Cheng, G. Pelicci, et al., Proc. Natl. Acad. Sci. U. S. A. 89, 8869 (1992). PubMed ID: 1409579

Source:SYKType of molecule:TyrKinase Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. Nagai, M. Takata, H. Yamamura, et al., J. Biol. Chem. 270, 6824 (1995). PubMed ID: 7896829

Source:PTPN2Type of molecule:TyrPhosphatase Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. T. Tiganis, A. M. Bennett, K. S. Ravichandran, et al., Mol. Cell. Biol. 18, 1622 (1998). PubMed ID: 9488479