Focal Adhesion Network Components

RHOA

Swiss-Prot Human Accession Code: P61586
List of interactions:

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:RHOAType of molecule:GTPase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. S. Kulkarni, D. E. Goll, J. E. Fox, J. Biol. Chem. 277, 24435 (2002). PubMed ID: 11964413

Source:ARHGAP26Type of molecule:GAP Location:FAC
Target:RHOAType of molecule:GTPase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. J. D. Hildebrand, J. M. Taylor, J. T. Parsons, Mol. Cell. Biol. 16, 3169 (1996). PubMed ID: 8649427

Source:p190GAPType of molecule:NA Location:NA
Target:RHOAType of molecule:GTPase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. P. D. Burbelo, S. Miyamoto, A. Utani, et al., J. Biol. Chem. 270, 30919 (1996). PubMed ID: 8537347

Source:PRKACAType of molecule:SerThrKinase Location:FACA
Target:RHOAType of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. P. Lang, F. Gesbert, M. Delespine-Carmagnat, et al., EMBO. J. 15, 510 (1996). PubMed ID: 8599934

Source:RHOAType of molecule:GTPase Location:FACA
Target:KTN1Type of molecule:Receptor Location:FAC
Type of interaction:Activation Effect:+
References:
1. K. Hotta, K. Tanaka, A. Mino, et al., Biochem. Biophys. Res. Commun. 225, 69 (1996). PubMed ID: 8769096

Source:RHOAType of molecule:GTPase Location:FACA
Target:PIP5K1CType of molecule:PtdInsKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. P. A. Weernink, K. Meletiadis, S. Hommeltenberg, et al., J. Biol. Chem. 279, 7840 (2004). PubMed ID: 14681219

Source:RHOAType of molecule:GTPase Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. J. Slater, J. L. Seiz, B. A. Stagliano, et al., Biochemistry. 40, 4437 (2001). PubMed ID: 11284700

Source:RHOAType of molecule:GTPase Location:FACA
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. K. Thodeti, R. Massoumi, L. Bindslev, et al., Biochem. J. 365, 157 (2002). PubMed ID: 12071848

Source:RHOAType of molecule:GTPase Location:FACA
Target:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. Y. Kabuyama, S. J. Langer, K. Polvinen, et al., Mol. Cell. Proteomics. 5, 1359 (2006). PubMed ID: 16644720

Source:RHOAType of molecule:GTPase Location:FACA
Target:ROCK1Type of molecule:SerThrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. Fujisawa, A. Fujita, T. Ishizaki, et al., J. Biol. Chem. 271, 23022 (1996). PubMed ID: 8798490

Source:RHOAType of molecule:GTPase Location:FACA
Target:PLD1Type of molecule:Phospholipase Location:FACA
Type of interaction:Activation Effect:+
References:
1. H. Genth, M. Schmidt, R. Gerhard, et al., Biochem. Biophys. Res. Commun. 302, 127 (2003). PubMed ID: 12593858

Source:ARHGAP5Type of molecule:GAP Location:FACA
Target:RHOAType of molecule:GTPase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. P. D. Burbelo, S. Miyamoto, A. Utani, et al., J. Biol. Chem. 270, 30919 (1996). PubMed ID: 8537347

Source:RICSType of molecule:GAP Location:FACA
Target:RHOAType of molecule:GTPase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. S. Y. Moon, H. Zang, Y. Zheng, J. Biol. Chem. 278, 4151 (2003). PubMed ID: 12454018

Source:TRIOType of molecule:GEF Location:FACA
Target:RHOAType of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. J. M. Bellanger, J. B. Lazaro, S. Diriong, et al., Oncogene. 16, 147 (1998). PubMed ID: 9464532

Source:VAV1Type of molecule:GEF Location:FACA
Target:RHOAType of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. D. Fischer, Y. Y. Kong, H. Nishina, et al., Curr. Biol. 8, 554 (1998). PubMed ID: 9601639