Focal Adhesion Network Components

RAC1

Swiss-Prot Human Accession Code: P15154
List of interactions:

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. T. Kwon, D. Y. Kwon, J. Chun, et al., J. Biol. Chem. 275, 423 (2000). PubMed ID: 10617634

Source:BCAR3Type of molecule:GEF Location:FACA
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. D. Cai, A. Iyer, K. N. Felekkis, et al., Cancer. Res. 63, 6802 (2003). PubMed ID: 14583477

Source:DOCK1Type of molecule:GEF Location:FAC
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. E. Brugnera, L. Haney, C. Grimsley, et al., Nat. Cell. Biol. 4, 574 (2002). PubMed ID: 12134158

Source:ELMO1Type of molecule:GEF Location:FAC
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. C. M. Grimsley, J. M. Kinchen, A. C. Tosello-Trampont, et al., J. Biol. Chem. 279, 6087 (2004). PubMed ID: 14638695

Source:FLNAType of molecule:ActinBinding Location:FAC
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Binding Effect:0
References:
1. J. M. Bellanger, C. Astier, C. Sardet, et al., Nat. Cell. Biol. 2, 888 (2001). PubMed ID: 11146652

Source:P190GAPType of molecule:NA Location:NA
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. P. D. Burbelo, S. Miyamoto, A. Utani, et al., J. Biol. Chem. 270, 30919 (1996). PubMed ID: 8537347

Source:ARHGEF6Type of molecule:GEF Location:FAC
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. et al., J. Cell. Biol. 172, 759 (2006). PubMed ID: 16492808

Source:RAC1Type of molecule:GTPase Location:FACA
Target:KTN1Type of molecule:Receptor Location:FAC
Type of interaction:Activation Effect:+
References:
1. K. Hotta, K. Tanaka, A. Mino, et al., Biochem. Biophys. Res. Commun. 225, 69 (1996). PubMed ID: 8769096

Source:RAC1Type of molecule:GTPase Location:FACA
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. W. Lu, B. J. Mayer, Oncogene. 18, 797 (1999). PubMed ID: 9989831

Source:RAC1Type of molecule:GTPase Location:FACA
Target:PIP5K1CType of molecule:PtdInsKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. t. e. n. PB,, J. P. Klooster, et al., J. Biol. Chem. 278, 39166 (2003). PubMed ID: 12874273

Source:RAC1Type of molecule:GTPase Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. J. Slater, J. L. Seiz, B. A. Stagliano, et al., Biochemistry. 40, 4437 (2001). PubMed ID: 11284700

Source:RAC1Type of molecule:GTPase Location:FACA
Target:STAT3Type of molecule:TF Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. R. Simon, H. G. Vikis, S. Stewart, et al., Science. 290, 144 (2000). PubMed ID: 11021801

Source:RAC1Type of molecule:GTPase Location:FACA
Target:TESK1Type of molecule:DualKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. Raymond, E. Bergeret, A. Avet-Rochex, et al., J. Cell. Sci. 117, 2777 (2004). PubMed ID: 15169836

Source:RAC1Type of molecule:GTPase Location:FACA
Target:PLD1Type of molecule:Phospholipase Location:FACA
Type of interaction:Activation Effect:+
References:
1. D. J. Powner, M. N. Hodgkin, M. J. Wakelam, Mol. Biol. Cell. 13, 1252 (2002). PubMed ID: 11950936

Source:RAC1Type of molecule:GTPase Location:FACA
Target:CRKType of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. t. e. n. PB,, J. P. Klooster, et al., J. Biol. Chem. 278, 39166 (2003). PubMed ID: 12874273

Source:ARHGAP24Type of molecule:GAP Location:FAC
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. I. Lavelin, B. Geiger, J. Biol. Chem. 280, 7178 (2005). PubMed ID: 15611138

Source:RICSType of molecule:GAP Location:FACA
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. S. Y. Moon, H. Zang, Y. Zheng, J. Biol. Chem. 278, 4151 (2003). PubMed ID: 12454018

Source:SOS1Type of molecule:RasGEF Location:FACA
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. A. S. Nimnual, B. A. Yatsula, D. Bar-Sagi, Science. 279, 560 (1998). PubMed ID: 9438849

Source:TIAM1Type of molecule:GEF Location:FACA
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. F. Michiels, G. G. Habets, J. C. Stam, et al., Nature. 375, 338 (1995). PubMed ID: 7753201

Source:TRIOType of molecule:GEF Location:FACA
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. J. M. Bellanger, J. B. Lazaro, S. Diriong, et al., Oncogene. 16, 147 (1998). PubMed ID: 9464532

Source:VAV1Type of molecule:GEF Location:FACA
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. D. Fischer, Y. Y. Kong, H. Nishina, et al., Curr. Biol. 8, 554 (1998). PubMed ID: 9601639