Focal Adhesion Network Components

PXN

Swiss-Prot Human Accession Code: P49023
List of interactions:

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. J. M. Lewis, M. A. Schwartz, J. Biol. Chem. 273, 14225 (1998). PubMed ID: 9603926

Source:ARF1Type of molecule:GTPase Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. J. C. Norman, D. Jones, S. T. Barry, et al., J. Cell. Biol. 143, 1981 (1999). PubMed ID: 9864369

Source:DDEF1Type of molecule:GAP Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. T. Oshiro, S. Koyama, S. Sugiyama, et al., J. Biol. Chem. 277, 38618 (2002). PubMed ID: 12149250

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. R. Yamaguchi, M. Maki, M. Hatanaka, et al., FEBS. Lett. 356, 114 (1995). PubMed ID: 7988702

Source:CEACAM1Type of molecule:Adhesion Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Ebrahimnejad, R. Flayeh, G. Unteregger, et al., Exp. Cell. Res. 260, 365 (2000). PubMed ID: 11035932

Source:CRKType of molecule:Cytoskeletal Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. D. Schaller, J. T. Parsons, Mol. Cell. Biol. 15, 2635 (1995). PubMed ID: 7537852

Source:CRKLType of molecule:Adapter Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. Salgia, N. Uemura, K. Okuda, et al., J. Biol. Chem. 270, 29145 (1996). PubMed ID: 7493940

Source:CSKType of molecule:TyrKinase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Bergman, V. Joukov, I. Virtanen, et al., Mol. Cell. Biol. 15, 711 (1995). PubMed ID: 7529872

Source:MAPK1Type of molecule:SerThrKinase Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. H. Ku, K. E. Meier, J. Biol. Chem. 275, 11333 (2000). PubMed ID: 10753946

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. D. Schaller, J. T. Parsons, Mol. Cell. Biol. 15, 2635 (1995). PubMed ID: 7537852

Source:FYNType of molecule:TyrKinase Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. M. Thomas, P. Soriano, A. Imamoto, Nature. 376, 267 (1995). PubMed ID: 7617039

Source:GAB1Type of molecule:Adaptor Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. Y. Ren, S. Meng, L. Mei, et al., J. Biol. Chem. 279, 8497 (2004). PubMed ID: 14665621

Source:GIT1Type of molecule:GAP Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. K. A. West, H. Zhang, M. C. Brown, et al., J. Cell. Biol. 154, 161 (2001). PubMed ID: 11448998

Source:HSPA2Type of molecule:Chaperone Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. H. Mao, Y. Wang, Z. Li, et al., J. Biol. Chem. 279, 15472 (2004). PubMed ID: 14718530

Source:ITGA5Type of molecule:Adhesion Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. Liu, S. M. Thomas, D. G. Woodside, et al., Nature. 402, 676 (2000). PubMed ID: 10604475

Source:ITGB1Type of molecule:Adhesion Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. L. M. Chen, D. Bailey, C. Fernandez-Valle, J. Neurosci. 20, 3776 (2000). PubMed ID: 10804218

Source:MAPK8Type of molecule:SerThrKinase Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. Huang, Z. Rajfur, C. Borchers, et al., Nature. 424, 219 (2003). PubMed ID: 12853963

Source:NF2Type of molecule:Cytoskeletal Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. C. Fernandez-Valle, Y. Tang, J. Ricard, et al., Nat. Genet. 31, 354 (2002). PubMed ID: 12118253

Source:RASA1Type of molecule:GAP Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Tsubouchi, J. Sakakura, R. Yagi, et al., J. Cell. Biol. 159, 673 (2002). PubMed ID: 12446743

Source:p190GAPType of molecule:NA Location:NA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. Y. Shikata, K. Shikata, M. Matsuda, et al., Biochem. Biophys. Res. Commun. 257, 234 (1999). PubMed ID: 10092539

Source:PABPC1Type of molecule:RNAMetabolism Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. J. Woods, T. Kantidakis, H. Sabe, et al., Mol. Cell. Biol. 25, 3763 (2005). PubMed ID: 15831480

Source:DDEF2Type of molecule:GAP Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Kondo, S. Hashimoto, H. Yano, et al., Mol. Biol. Cell. 11, 1315 (2000). PubMed ID: 10749932

Source:PARVAType of molecule:Cytoskeletal Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. N. Nikolopoulos, C. E. Turner, J. Cell. Biol. 151, 1435 (2001). PubMed ID: 11134073

Source:PXNType of molecule:Adapter Location:FAC
Target:NUDT16L1Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. F. Denhez, S. A. Wilcox-Adelman, P. C. Baciu, et al., J. Biol. Chem. 277, 12270 (2002). PubMed ID: 11805099

Source:PXNType of molecule:Adapter Location:FAC
Target:KALPHA1Type of molecule:Cytoskeletal Location:FACA
Type of interaction:Binding Effect:0
References:
1. M. C. Brown, C. E. Turner, Int. J. Biochem. Cell. Biol. 34, 855 (2002). PubMed ID: 11950600

Source:PXNType of molecule:Adapter Location:FAC
Target:ILKType of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. N. Nikolopoulos, C. E. Turner, J. Biol. Chem. 276, 23499 (2001). PubMed ID: 11304546

Source:PXNType of molecule:Adapter Location:FAC
Target:VCLType of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. C. E. Turner, J. T. Miller, J. Cell. Sci. 107, 1583 (1994). PubMed ID: 7525621

Source:SORBS1Type of molecule:Adapter Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Zhang, J. Liu, A. Cheng, et al., EMBO. J. 25, 5284 (2006). PubMed ID: 17082770

Source:PPP2CAType of molecule:SerThrPhosphatase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. J. L. Jackson, M. R. Young, Clin. Exp. Metastasis. 19, 409 (2002). PubMed ID: 12198769

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. Y. Shen, G. Schneider, J. F. Cloutier, et al., J. Biol. Chem. 273, 6474 (1998). PubMed ID: 9497381

Source:PTPROType of molecule:TyrPhosphatase Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. F. J. Pixley, P. S. Lee, J. S. Condeelis, et al., Mol. Cell. Biol. 21, 1795 (2001). PubMed ID: 11238916

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. J. Keogh, R. A. Houliston, C. P. Wheeler-Jones, Biochem. Biophys. Res. Commun. 290, 1470 (2002). PubMed ID: 11820787

Source:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. Y. Ren, S. Meng, L. Mei, et al., J. Biol. Chem. 279, 8497 (2004). PubMed ID: 14665621

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. J. R. Glenney, J. Cell. Biol. 108, 2401 (1989). PubMed ID: 2472406

Source:SYKType of molecule:TyrKinase Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. R. Fernandez, S. J. Suchard, J. Immunol. 160, 5154 (1998). PubMed ID: 9590268

Source:SORBS3Type of molecule:Cytoskeletal Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Zhang, J. Liu, A. Cheng, et al., EMBO. J. 25, 5284 (2006). PubMed ID: 17082770