Focal Adhesion Network Components

PTPN6

Swiss-Prot Human Accession Code: P29350
List of interactions:

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. Kharbanda, A. Bharti, D. Pei, et al., Proc. Natl. Acad. Sci. U. S. A. 93, 6898 (1996). PubMed ID: 8692915

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. H. Falet, S. Pain, F. Rendu, Biochem. Biophys. Res. Commun. 252, 51 (1998). PubMed ID: 9813145

Source:CEACAM1Type of molecule:Adhesion Location:FACA
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Huber, L. Izzi, P. Grondin, et al., J. Biol. Chem. 274, 335 (1999). PubMed ID: 9867848

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. P. Minoo, M. M. Zadeh, R. Rottapel, et al., Blood. 103, 1398 (2004). PubMed ID: 14551136

Source:INSRType of molecule:Receptor Location:FACA
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. T. Uchida, T. Matozaki, T. Noguchi, et al., J. Biol. Chem. 269, 12220 (1994). PubMed ID: 7512963

Source:LYNType of molecule:TyrKinase Location:FACA
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. K. Yoshida, S. Kharbanda, D. Kufe, J. Biol. Chem. 274, 34663 (2000). PubMed ID: 10574931

Source:PIP3Type of molecule:Lipid Location:FACA
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. Frank, H. Keilhack, F. Opitz, et al., Biochemistry. 38, 11993 (1999). PubMed ID: 10508402

Source:PIP5K1CType of molecule:PtdInsKinase Location:FACA
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. F. Bairstow, K. Ling, R. A. Anderson, J. Biol. Chem. 280, 23884 (2005). PubMed ID: 15849189

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. V. Strack, J. Krutzfeldt, M. Kellerer, et al., Biochemistry. 41, 603 (2002). PubMed ID: 11781100

Source:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Target:ACTN1Type of molecule:Actinbundling Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. S. Y. Lin, S. Raval, Z. Zhang, et al., J. Biol. Chem. 279, 25755 (2004). PubMed ID: 15070900

Source:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. R. D. Chernock, R. P. Cherla, R. K. Ganju, Blood. 97, 608 (2001). PubMed ID: 11157475

Source:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Target:LYNType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. K. Yoshida, S. Kharbanda, D. Kufe, J. Biol. Chem. 274, 34663 (2000). PubMed ID: 10574931

Source:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Target:SIRPAType of molecule:Receptor Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. J. Yang, Z. Cheng, T. Niu, et al., J. Biol. Chem. 275, 4066 (2000). PubMed ID: 10660565

Source:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. A. K. Somani, J. S. Bignon, G. B. Mills, et al., J. Biol. Chem. 272, 21113 (1997). PubMed ID: 9261115

Source:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. J. Brockdorff, S. Williams, C. Couture, et al., Eur. J. Immunol. 29, 2539 (1999). PubMed ID: 10458769

Source:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. M. Kon-Kozlowski, G. Pani, T. Pawson, et al., J. Biol. Chem. 271, 3856 (1996). PubMed ID: 8632004