Focal Adhesion Network Components

PTPN12

Swiss-Prot Human Accession Code: Q05209
List of interactions:

Source:CSKType of molecule:TyrKinase Location:FAC
Target:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. D. Davidson, J. F. Cloutier, A. Gregorieff, et al., J. Biol. Chem. 272, 23455 (1997). PubMed ID: 9287362

Source:FLNAType of molecule:ActinBinding Location:FAC
Target:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. P. Playford, P. D. Lyons, S. K. Sastry, et al., J. Biol. Chem. 281, 34104 (2006). PubMed ID: 16973606

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Charest, J. Wagner, M. Kwan, et al., Oncogene. 14, 1643 (1997). PubMed ID: 9135065

Source:TGFB1I1Type of molecule:Adapter Location:FAC
Target:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. N. Nishiya, Y. Iwabuchi, M. Shibanuma, et al., J. Biol. Chem. 274, 9847 (1999). PubMed ID: 10092676

Source:LPXNType of molecule:Adapter Location:FAC
Target:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. N. Watanabe, N. Amano, H. Ishizuka, et al., Mol. Cell. Biochem. 269, 13 (2005). PubMed ID: 15786712

Source:PRKACAType of molecule:SerThrKinase Location:FACA
Target:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. A. J. Garton, N. K. Tonks, EMBO. J. 13, 3763 (1994). PubMed ID: 7520867

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. A. J. Garton, N. K. Tonks, EMBO. J. 13, 3763 (1994). PubMed ID: 7520867

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:ABL1Type of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. F. Cong, S. Spencer, J. F. Cote, et al., Mol. Cell. 6, 1413 (2001). PubMed ID: 11163214

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. A. J. Garton, A. J. Flint, N. K. Tonks, Mol. Cell. Biol. 16, 6408 (1996). PubMed ID: 8887669

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:NEDD9Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. J. F. Cote, A. Charest, J. Wagner, et al., Biochemistry. 37, 13128 (1998). PubMed ID: 9748319

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:p190GAPType of molecule:NA Location:NA
Type of interaction:Inhibition Effect:_
References:
1. S. K. Sastry, Z. Rajfur, B. P. Liu, et al., J. Biol. Chem. 281, 11627 (2006). PubMed ID: 16513648

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. Y. Shen, G. Schneider, J. F. Cloutier, et al., J. Biol. Chem. 273, 6474 (1998). PubMed ID: 9497381

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. P. D. Lyons, J. M. Dunty, E. M. Schaefer, et al., J. Biol. Chem. 276, 24422 (2001). PubMed ID: 11337490

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. T. Habib, R. Herrera, S. J. Decker, J. Biol. Chem. 269, 25243 (1994). PubMed ID: 7929214

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. S. K. Sastry, Z. Rajfur, B. P. Liu, et al., J. Biol. Chem. 281, 11627 (2006). PubMed ID: 16513648