Focal Adhesion Network Components

PTPN11

Swiss-Prot Human Accession Code: Q06124
List of interactions:

Source:CEACAM1Type of molecule:Adhesion Location:FACA
Target:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Huber, L. Izzi, P. Grondin, et al., J. Biol. Chem. 274, 335 (1999). PubMed ID: 9867848

Source:FYNType of molecule:TyrKinase Location:FACA
Target:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. H. Tang, Z. J. Zhao, X. Y. Huang, et al., J. Biol. Chem. 274, 12401 (1999). PubMed ID: 10212213

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. L. Wong, G. R. Johnson, J. Biol. Chem. 271, 20981 (1996). PubMed ID: 8702859

Source:INSRType of molecule:Receptor Location:FACA
Target:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. H. Maegawa, S. Ugi, M. Adachi, et al., Biochem. Biophys. Res. Commun. 199, 780 (1994). PubMed ID: 8135823

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. V. Strack, J. Krutzfeldt, M. Kellerer, et al., Biochemistry. 41, 603 (2002). PubMed ID: 11781100

Source:SHC1Type of molecule:Adapter Location:FACA
Target:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. L. Delahaye, S. Rocchi, Endocrinology. 141, 621 (2000). PubMed ID: 10650943

Source:INPP5DType of molecule:PtdInsPhosphatase Location:FAC
Target:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. L. Liu, J. E. Damen, M. D. Ware, et al., J. Biol. Chem. 272, 10998 (1997). PubMed ID: 9110989

Source:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. S. Manes, E. Mira, C. Gomez-Mouton, et al., Mol. Cell. Biol. 19, 3125 (1999). PubMed ID: 10082579

Source:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. S. Tanaka, L. Mohr, E. V. Schmidt, et al., Hepatology. 26, 598 (1997). PubMed ID: 9303488

Source:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. Y. Ren, S. Meng, L. Mei, et al., J. Biol. Chem. 279, 8497 (2004). PubMed ID: 14665621

Source:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. D. Chauhan, P. Pandey, T. Hideshima, et al., J. Biol. Chem. 275, 27845 (2000). PubMed ID: 10880513

Source:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Target:SIRPAType of molecule:Receptor Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. A. Kharitonenkov, Z. Chen, I. Sures, et al., Nature. 386, 181 (1997). PubMed ID: 9062191

Source:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Target:STAT3Type of molecule:TF Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. H. Kim, H. Baumann, Mol. Cell. Biol. 19, 5326 (1999). PubMed ID: 10409724

Source:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Target:GAB1Type of molecule:Adaptor Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. C. Lecoq-Lafon, F. Verdier, S. Fichelson, et al., Blood. 93, 2578 (1999). PubMed ID: 10194437