Focal Adhesion Network Components

PTPN1

Swiss-Prot Human Accession Code: P18031
List of interactions:

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. L. V. Ravichandran, H. Chen, Y. Li, et al., Mol. Endocrinol. 15, 1768 (2001). PubMed ID: 11579209

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. J. V. Frangioni, A. Oda, M. Smith, et al., EMBO. J. 12, 4843 (1993). PubMed ID: 8223493

Source:CAV1Type of molecule:Cytoskeletal Location:FAC
Target:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Caselli, B. Mazzinghi, G. Camici, et al., Biochem. Biophys. Res. Commun. 296, 692 (2002). PubMed ID: 12176037

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Type of interaction:Binding Effect:0
References:
1. B. J. Goldstein, A. Bittner-Kowalczyk, M. F. White, et al., J. Biol. Chem. 275, 4283 (2000). PubMed ID: 10660596

Source:INSRType of molecule:Receptor Location:FACA
Target:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. Dadke, A. Kusari, J. Kusari, Mol. Cell. Biochem. 221, 147 (2001). PubMed ID: 11506178

Source:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Target:ACTN1Type of molecule:Actinbundling Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. Z. Zhang, S. Y. Lin, B. G. Neel, et al., J. Biol. Chem. 281, 1746 (2006). PubMed ID: 16291744

Source:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. F. Liu, D. E. Hill, J. Chernoff, J. Biol. Chem. 271, 31290 (1997). PubMed ID: 8940134

Source:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. B. J. Goldstein, A. Bittner-Kowalczyk, M. F. White, et al., J. Biol. Chem. 275, 4283 (2000). PubMed ID: 10660596

Source:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. C. J. Pallen, D. S. Lai, H. P. Chia, et al., Biochem. J. 276, 315 (1991). PubMed ID: 1646596

Source:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Target:INSRType of molecule:Receptor Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. X. Espanel, M. Huguenin-Reggiani, Protein. Sci. 11, 2326 (2002). PubMed ID: 12237455

Source:RHOAType of molecule:GTPase Location:FACA
Target:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. Y. Kabuyama, S. J. Langer, K. Polvinen, et al., Mol. Cell. Proteomics. 5, 1359 (2006). PubMed ID: 16644720