Focal Adhesion Network Components

PTK2B

Swiss-Prot Human Accession Code: Q14289
List of interactions:

Source:ABI1Type of molecule:Adapter Location:FACA
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. H. Schmidt, B. Chen, L. M. Randazzo, et al., J. Cell. Sci. 116, 2845 (2003). PubMed ID: 12771190

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. Zrihan-Licht, S. Avraham, S. Jiang, et al., Int. J. Oncol. 24, 153 (2003). PubMed ID: 14654952

Source:SORBS2Type of molecule:Adapter Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Ronty, A. Taivainen, M. Moza, et al., Exp. Cell. Res. 310, 88 (2005). PubMed ID: 16125169

Source:BCAR1Type of molecule:Cytoskeletal Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Astier, H. Avraham, S. N. Manie, et al., J. Biol. Chem. 272, 228 (1997). PubMed ID: 8995252

Source:CBLType of molecule:E3ligase Location:FACA
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Sanjay, A. Houghton, L. Neff, et al., J. Cell. Biol. 152, 181 (2001). PubMed ID: 11149930

Source:FYNType of molecule:TyrKinase Location:FACA
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. D. Qian, S. Lev, et al., J. Exp. Med. 185, 1253 (1997). PubMed ID: 9104812

Source:ARHGAP26Type of molecule:GAP Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. W. C. Xiong, M. Macklem, J. T. Parsons, J. Cell. Sci. 111, 1981 (1998). PubMed ID: 9645946

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. T. Ohmori, Y. Yatomi, N. Asazuma, et al., Biochem. J. 347, 561 (2001). PubMed ID: 10749687

Source:ITGB1Type of molecule:Adhesion Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. B. Butler, S. D. Blystone, J. Biol. Chem. 280, 14556 (2005). PubMed ID: 15695828

Source:LPXNType of molecule:Adapter Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. B. P. Lipsky, C. R. Beals, D. E. Staunton, J. Biol. Chem. 273, 11709 (1998). PubMed ID: 9565592

Source:LYNType of molecule:TyrKinase Location:FACA
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Yamasaki, H. Arai, N. Ashida, et al., Biochem. J. 355, 751 (2001). PubMed ID: 11311138

Source:PDPK1Type of molecule:SerThrKinase Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. Y. Taniyama, D. S. Weber, P. Rocic, et al., Mol. Cell. Biol. 23, 8019 (2003). PubMed ID: 14585963

Source:PIK3CAType of molecule:PtdInsKinase Location:FACA
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. K. Koziak, E. Kaczmarek, S. Y. Park, et al., Br. J. Haematol. 114, 134 (2001). PubMed ID: 11472358

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. P. D. Lyons, J. M. Dunty, E. M. Schaefer, et al., J. Biol. Chem. 276, 24422 (2001). PubMed ID: 11337490

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:SH3KBP1Type of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. H. Schmidt, B. Chen, L. M. Randazzo, et al., J. Cell. Sci. 116, 2845 (2003). PubMed ID: 12771190

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:TGFB1I1Type of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. Osada, T. Ohmori, Y. Yatomi, et al., Biochem. J. 355, 691 (2001). PubMed ID: 11311131

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:DDEF2Type of molecule:GAP Location:FAC
Type of interaction:Activation Effect:+
References:
1. J. Andreev, J. P. Simon, D. D. Sabatini, et al., Mol. Cell. Biol. 19, 2338 (1999). PubMed ID: 10022920

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. J. Keogh, R. A. Houliston, C. P. Wheeler-Jones, Biochem. Biophys. Res. Commun. 290, 1470 (2002). PubMed ID: 11820787

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Jeschke, G. J. Standke, M. Scaronuscarona, J. Biol. Chem. 273, 11354 (1998). PubMed ID: 9556630

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. R. K. Ganju, S. A. Brubaker, R. D. Chernock, et al., J. Biol. Chem. 275, 17263 (2000). PubMed ID: 10747947

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. T. Katagiri, T. Takahashi, T. Sasaki, et al., J. Biol. Chem. 275, 19645 (2000). PubMed ID: 10867021

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. et al., Mol. Biol. Cell. 17, 3508 (2006). PubMed ID: 16760434

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:DDEF1Type of molecule:GAP Location:FAC
Type of interaction:Activation Effect:+
References:
1. A. Kruljac-Letunic, J. Moelleken, A. Kallin, et al., J. Biol. Chem. 278, 29560 (2003). PubMed ID: 12771146

Source:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. D. Chauhan, P. Pandey, T. Hideshima, et al., J. Biol. Chem. 275, 27845 (2000). PubMed ID: 10880513