Focal Adhesion Network Components

PTK2

Swiss-Prot Human Accession Code: Q05397
List of interactions:

Source:ABI1Type of molecule:Adapter Location:FACA
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. H. Schmidt, B. Chen, L. M. Randazzo, et al., J. Cell. Sci. 116, 2845 (2003). PubMed ID: 12771190

Source:DDEF1Type of molecule:GAP Location:FAC
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. Y. Liu, J. C. Loijens, K. H. Martin, et al., Mol. Biol. Cell. 13, 2147 (2002). PubMed ID: 12058076

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. P. Cooray, Y. Yuan, S. M. Schoenwaelder, et al., Biochem. J. 318, 41 (1996). PubMed ID: 8761450

Source:BCAR1Type of molecule:Cytoskeletal Location:FAC
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. B. Kovacic-Milivojevic, F. Roediger, E. A. Almeida, et al., Mol. Biol. Cell. 12, 2290 (2001). PubMed ID: 11514617

Source:CSKType of molecule:TyrKinase Location:FAC
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Bergman, V. Joukov, I. Virtanen, et al., Mol. Cell. Biol. 15, 711 (1995). PubMed ID: 7529872

Source:DNM2Type of molecule:GTPase Location:FAC
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. Kharbanda, A. Saleem, Z. Yuan, et al., Proc. Natl. Acad. Sci. U. S. A. 92, 6132 (1995). PubMed ID: 7597091

Source:VIL2Type of molecule:Cytoskeletal Location:FAC
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. P. Poullet, A. Gautreau, G. Kadare, et al., J. Biol. Chem. 276, 37686 (2001). PubMed ID: 11468295

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:ACTN1Type of molecule:Actinbundling Location:FAC
Type of interaction:Activation Effect:+
References:
1. G. Izaguirre, L. Aguirre, Y. P. Hu, et al., J. Biol. Chem. 276, 28676 (2001). PubMed ID: 11369769

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:SH3KBP1Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. H. Schmidt, B. Chen, L. M. Randazzo, et al., J. Cell. Sci. 116, 2845 (2003). PubMed ID: 12771190

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:FHL2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. B. Gabriel, S. Mildenberger, C. W. Weisser, et al., Anticancer. Res. 24, 921 (2004). PubMed ID: 15161045

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:FYNType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. S. T. Arold, T. S. Ulmer, T. D. Mulhern, et al., J. Biol. Chem. 276, 17199 (2001). PubMed ID: 11278857

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:GIT1Type of molecule:GAP Location:FAC
Type of interaction:Activation Effect:+
References:
1. Z. S. Zhao, E. Manser, T. H. Loo, et al., Mol. Cell. Biol. 20, 6354 (2000). PubMed ID: 10938112

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:ARHGAP26Type of molecule:GAP Location:FAC
Type of interaction:Binding Effect:0
References:
1. J. M. Taylor, M. M. Macklem, J. T. Parsons, J. Cell. Sci. 112, 231 (1999). PubMed ID: 9858476

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:GRB2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. D. D. Schlaepfer, S. K. Hanks, T. Hunter, et al., Nature. 372, 786 (1995). PubMed ID: 7997267

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:GRB7Type of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. D. C. Han, J. L. Guan, J. Biol. Chem. 274, 24425 (1999). PubMed ID: 10446223

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:NEDD9Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. F. Law, J. Estojak, B. Wang, et al., Mol. Cell. Biol. 16, 3327 (1996). PubMed ID: 8668148

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:KCNH2Type of molecule:Channel Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Cherubini, G. Hofmann, S. Pillozzi, et al., Mol. Biol. Cell. 16, 2972 (2005). PubMed ID: 15800067

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:TGFB1I1Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. M. Thomas, M. Hagel, C. E. Turner, J. Cell. Sci. 112, 181 (1999). PubMed ID: 9858471

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:HSPA2Type of molecule:Chaperone Location:FACA
Type of interaction:Binding Effect:0
References:
1. H. Mao, F. Li, K. Ruchalski, et al., J. Biol. Chem. 278, 18214 (2003). PubMed ID: 12611892

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:ITGA5Type of molecule:Adhesion Location:FAC
Type of interaction:Binding Effect:0
References:
1. B. P. Eliceiri, X. S. Puente, J. D. Hood, et al., J. Cell. Biol. 157, 149 (2002). PubMed ID: 11927607

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:ITGB1Type of molecule:Adhesion Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. Bergan, E. Kyle, P. Nguyen, et al., Clin. Exp. Metastasis. 14, 389 (1996). PubMed ID: 8878413

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. S. Manes, E. Mira, C. Gomez-Mouton, et al., Mol. Cell. Biol. 19, 3125 (1999). PubMed ID: 10082579

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:MAPK8IP3Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. T. Takino, M. Nakada, H. Miyamori, et al., J. Biol. Chem. 280, 37772 (2005). PubMed ID: 16141199

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:LYNType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. I. Mlinaric-Rascan, T. Yamamoto, FEBS. Lett. 498, 26 (2001). PubMed ID: 11389892

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:NCK2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. M. Goicoechea, Y. Tu, Y. Hua, et al., Int. J. Biochem. Cell. Biol. 34, 791 (2002). PubMed ID: 11950595

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:p190GAPType of molecule:NA Location:NA
Type of interaction:Activation Effect:+
References:
1. M. Holinstat, N. Knezevic, M. Broman, et al., J. Biol. Chem. 281, 2296 (2006). PubMed ID: 16308318

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. D. Schaller, J. T. Parsons, Mol. Cell. Biol. 15, 2635 (1995). PubMed ID: 7537852

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. C. Guinebault, B. Payrastre, C. Racaud-Sultan, et al., J. Cell. Biol. 129, 831 (1995). PubMed ID: 7537275

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. X. Zhang, A. Chattopadhyay, Q. S. Ji, et al., Proc. Natl. Acad. Sci. U. S. A. 96, 9021 (1999). PubMed ID: 10430888

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:SORBS1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. V. Ribon, R. Herrera, B. K. Kay, et al., J. Biol. Chem. 273, 4073 (1998). PubMed ID: 9461600

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. D. D. Schlaepfer, K. C. Jones, T. Hunter, Mol. Cell. Biol. 18, 2571 (1998). PubMed ID: 9566877

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. K. Sada, Y. Minami, H. Yamamura, Eur. J. Biochem. 248, 827 (1997). PubMed ID: 9342235

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:TLN1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. H. C. Chen, P. A. Appeddu, J. T. Parsons, et al., J. Biol. Chem. 270, 16995 (1995). PubMed ID: 7622520

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:TRIOType of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. Q. G. Medley, E. G. Buchbinder, K. Tachibana, et al., J. Biol. Chem. 278, 13265 (2003). PubMed ID: 12551902

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:ARHGEF6Type of molecule:GEF Location:FAC
Type of interaction:Activation Effect:+
References:
1. F. Chang, C. A. Lemmon, D. Park, et al., Mol. Biol. Cell. 18, 253 (2006). PubMed ID: 17093062

Source:INSRType of molecule:Receptor Location:FACA
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. V. Baron, V. Calleja, P. Ferrari, et al., J. Biol. Chem. 273, 7162 (1998). PubMed ID: 9507031

Source:PTENType of molecule:PtdInsPhosphatase Location:FACA
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. M. Tamura, J. Gu, K. Matsumoto, et al., Science. 280, 1614 (1998). PubMed ID: 9616126

Source:PTK2BType of molecule:TyrKinase Location:FAC
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. et al., Mol. Biol. Cell. 17, 3508 (2006). PubMed ID: 16760434

Source:PTPRHType of molecule:TyrPhosphatase Location:FACA
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. T. Noguchi, M. Tsuda, H. Takeda, et al., J. Biol. Chem. 276, 15216 (2001). PubMed ID: 11278335

Source:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. S. Manes, E. Mira, C. Gomez-Mouton, et al., Mol. Cell. Biol. 19, 3125 (1999). PubMed ID: 10082579

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. B. Calalb, T. R. Polte, S. K. Hanks, Mol. Cell. Biol. 15, 954 (1995). PubMed ID: 7529876

Source:THY1Type of molecule:Adhesion Location:FACA
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. T. A. Rege, M. A. Pallero, C. Gomez, et al., Exp. Cell. Res. 312, 3752 (2006). PubMed ID: 17027000