Focal Adhesion Network Components

PTEN

Swiss-Prot Human Accession Code: P60484
List of interactions:

Source:CAV1Type of molecule:Cytoskeletal Location:FAC
Target:PTENType of molecule:PtdInsPhosphatase Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Caselli, B. Mazzinghi, G. Camici, et al., Biochem. Biophys. Res. Commun. 296, 692 (2002). PubMed ID: 12176037

Source:PTENType of molecule:PtdInsPhosphatase Location:FACA
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. M. Tamura, J. Gu, K. Matsumoto, et al., Science. 280, 1614 (1998). PubMed ID: 9616126

Source:PTENType of molecule:PtdInsPhosphatase Location:FACA
Target:PIP3Type of molecule:Lipid Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. T. Maehama, J. E. Dixon, J. Biol. Chem. 273, 13375 (1998). PubMed ID: 9593664

Source:PTENType of molecule:PtdInsPhosphatase Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. J. Gu, M. Tamura, R. Pankov, et al., J. Cell. Biol. 146, 389 (1999). PubMed ID: 10427092

Source:ROCK1Type of molecule:SerThrKinase Location:FACA
Target:PTENType of molecule:PtdInsPhosphatase Location:FACA
Type of interaction:Activation Effect:+
References:
1. Z. Li, X. Dong, Z. Wang, et al., Nat. Cell. Biol. 7, 399 (2005). PubMed ID: 15793569