Focal Adhesion Network Components

PRKCA

Swiss-Prot Human Accession Code: P17252
List of interactions:

Source:ACTBType of molecule:Cytoskeletal Location:FAC
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. N. D. Smallwood, B. S. Hausman, X. Wang, et al., Am. J. Physiol. Cell. Physiol. 288, C906 (2005). PubMed ID: 15590896

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. B. Bauer, N. Krumbock, F. Fresser, et al., J. Biol. Chem. 276, 31627 (2001). PubMed ID: 11410591

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. T. B. Shea, M. L. Beermann, W. R. Griffin, et al., FEBS. Lett. 350, 223 (1994). PubMed ID: 8070569

Source:DAGType of molecule:Lipid Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. G. Carpenter, Q. Ji, Exp. Cell. Res. 253, 15 (1999). PubMed ID: 10579907

Source:VIL2Type of molecule:Cytoskeletal Location:FAC
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. F. Pietromonaco, P. C. Simons, A. Altman, et al., J. Biol. Chem. 273, 7594 (1998). PubMed ID: 9516463

Source:FYNType of molecule:TyrKinase Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. D. Crosby, A. W. Poole, J. Biol. Chem. 278, 24533 (2003). PubMed ID: 12721299

Source:IRS1Type of molecule:Adapter Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. Nawaratne, A. Gray, C. H. Jorgensen, et al., Mol. Endocrinol. 20, 1838 (2006). PubMed ID: 16574739

Source:LYNType of molecule:TyrKinase Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. A. Pace, J. A. Tapia, L. J. Garcia-Marin, et al., Biochim. Biophys. Acta. 1763, 356 (2006). PubMed ID: 16713446

Source:PDPK1Type of molecule:SerThrKinase Location:FAC
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. A. Balendran, G. R. Hare, A. Kieloch, et al., FEBS. Lett. 484, 217 (2000). PubMed ID: 11078882

Source:PIP3Type of molecule:Lipid Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. S. Singh, A. Chauhan, H. Brockerhoff, et al., Biochem. Biophys. Res. Commun. 195, 104 (1993). PubMed ID: 8395820

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:CAPN1Type of molecule:CysProtease Location:FACA
Type of interaction:Activation Effect:+
References:
1. B. J. Perrin, A. Huttenlocher, Int. J. Biochem. Cell. Biol. 34, 722 (2002). PubMed ID: 11950589

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:FLNAType of molecule:ActinBinding Location:FAC
Type of interaction:Activation Effect:+
References:
1. U. Tigges, B. Koch, J. Wissing, et al., J. Biol. Chem. 278, 23561 (2003). PubMed ID: 12704190

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:ITGB1Type of molecule:Adhesion Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. Fagerholm, N. Morrice, C. G. Gahmberg, et al., J. Biol. Chem. 277, 1728 (2002). PubMed ID: 11700305

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:INSRType of molecule:Receptor Location:FACA
Type of interaction:Activation Effect:+
References:
1. J. Ahn, D. B. Donner, O. M. Rosen, J. Biol. Chem. 268, 7571 (1993). PubMed ID: 8463287

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:MARCKSType of molecule:ActinBundling Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. Dulong, S. Goudenege, K. Vuillier-Devillers, et al., Biochem. J. 382, 1015 (2004). PubMed ID: 15239673

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. F. Bennett, S. T. Crooke, J. Biol. Chem. 262, 13789 (1987). PubMed ID: 2820980

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. A. J. Garton, N. K. Tonks, EMBO. J. 13, 3763 (1994). PubMed ID: 7520867

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:PTPRAType of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. D. T. Brandt, A. Goerke, M. Heuer, et al., et al., J. Biol. Chem. 278, 34073 (2003). PubMed ID: 12826681

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:GNB2L1Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. D. Ron, C. H. Chen, J. Caldwell, et al., Proc. Natl. Acad. Sci. U. S. A. 91, 839 (1994). PubMed ID: 8302854

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Faisal, M. el-Shemerly, D. Hess, et al., J. Biol. Chem. 277, 30144 (2002). PubMed ID: 12052829

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. V. Strack, J. Krutzfeldt, M. Kellerer, et al., Biochemistry. 41, 603 (2002). PubMed ID: 11781100

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. V. Strack, J. Krutzfeldt, M. Kellerer, et al., Biochemistry. 41, 603 (2002). PubMed ID: 11781100

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. K. L. Gould, J. R. Woodgett, J. A. Cooper, et al., Cell. 42, 849 (1985). PubMed ID: 2996780

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:STAT3Type of molecule:TF Location:FAC
Type of interaction:Activation Effect:+
References:
1. N. Jain, T. Zhang, W. H. Kee, et al., J. Biol. Chem. 274, 24392 (1999). PubMed ID: 10446219

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. P. Borowski, M. Heiland, L. Kornetzky, et al., Biochem. J. 331, 649 (1998). PubMed ID: 9531509

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:SDC4Type of molecule:Adhesion Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. Murakami, A. Horowitz, S. Tang, et al., J. Biol. Chem. 277, 20367 (2002). PubMed ID: 11916978

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:TSPAN1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. X. A. Zhang, A. L. Bontrager, M. E. Hemler, J. Biol. Chem. 276, 25005 (2001). PubMed ID: 11325968

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:TIAM1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. F. G. Buchanan, C. M. Elliot, M. Gibbs, et al., J. Biol. Chem. 275, 9742 (2000). PubMed ID: 10734127

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:VASPType of molecule:ActinBinding Location:FAC
Type of interaction:Activation Effect:+
References:
1. K. Chitaley, L. Chen, A. Galler, et al., FEBS. Lett. 556, 211 (2004). PubMed ID: 14706852

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:VIMType of molecule:Cytoskeletal Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. Ando, K. Tanabe, Y. Gonda, et al., Biochemistry. 28, 2974 (1989). PubMed ID: 2500966

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:VCLType of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. W. H. Ziegler, U. Tigges, A. Zieseniss, et al., J. Biol. Chem. 277, 7396 (2002). PubMed ID: 11741957

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:TLN1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. D. W. Litchfield, E. H. Ball, Biochem. Biophys. Res. Commun. 134, 1276 (1986). PubMed ID: 3080999

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. Y. Li, T. J. Soos, X. Li, et al., J. Biol. Chem. 279, 45304 (2004). PubMed ID: 15364919

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Activation Effect:+
References:
1. G. Pedraza-Alva, S. Sawasdikosol, Y. C. Liu, et al., J. Biol. Chem. 276, 729 (2001). PubMed ID: 11024037

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:VIL2Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. T. Ng, M. Parsons, W. E. Hughes, et al., EMBO. J. 20, 2723 (2001). PubMed ID: 11387207

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:PLD1Type of molecule:Phospholipase Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. M. Conricode, K. A. Brewer, J. H. Exton, J. Biol. Chem. 267, 7199 (1992). PubMed ID: 1559964

Source:PPP2CAType of molecule:SerThrPhosphatase Location:FAC
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. R. Ricciarelli, A. Azzi, Arch. Biochem. Biophys. 355, 197 (1998). PubMed ID: 9675027

Source:RAC1Type of molecule:GTPase Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. J. Slater, J. L. Seiz, B. A. Stagliano, et al., Biochemistry. 40, 4437 (2001). PubMed ID: 11284700

Source:RHOAType of molecule:GTPase Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. J. Slater, J. L. Seiz, B. A. Stagliano, et al., Biochemistry. 40, 4437 (2001). PubMed ID: 11284700

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. L. Seibenhener, J. Roehm, W. O. White, et al., Mol. Cell. Biol. Res. Commun. 2, 28 (2000). PubMed ID: 10527887

Source:SYKType of molecule:TyrKinase Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. G. Pula, D. Crosby, J. Baker, et al., J. Biol. Chem. 280, 7194 (2005). PubMed ID: 15583006