Focal Adhesion Network Components

PLCG1

Swiss-Prot Human Accession Code: P19174
List of interactions:

Source:CBLType of molecule:E3ligase Location:FACA
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. D. Tvorogov, G. Carpenter, Exp. Cell. Res. 277, 86 (2002). PubMed ID: 12061819

Source:DNM2Type of molecule:GTPase Location:FAC
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. Scaife, I. Gout, M. D. Waterfield, et al., EMBO. J. 13, 2574 (1994). PubMed ID: 8013457

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. X. Zhang, A. Chattopadhyay, Q. S. Ji, et al., Proc. Natl. Acad. Sci. U. S. A. 96, 9021 (1999). PubMed ID: 10430888

Source:FYNType of molecule:TyrKinase Location:FACA
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. M. Pleiman, M. R. Clark, L. K. Gauen, et al., Mol. Cell. Biol. 13, 5877 (1993). PubMed ID: 8395016

Source:GIT1Type of molecule:GAP Location:FAC
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. J. Hoefen, B. C. Berk, J. Cell. Sci. 119, 1469 (2006). PubMed ID: 16598076

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. Z. Pei, J. A. Maloney, L. Yang, et al., Arch. Biochem. Biophys. 345, 103 (1997). PubMed ID: 9281317

Source:LYNType of molecule:TyrKinase Location:FACA
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. M. Pleiman, M. R. Clark, L. K. Gauen, et al., Mol. Cell. Biol. 13, 5877 (1993). PubMed ID: 8395016

Source:PAK1Type of molecule:SerThrKinase Location:FAC
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. K. S. Shin, E. Y. Shin, C. S. Lee, et al., Exp. Mol. Med. 34, 172 (2002). PubMed ID: 12085993

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. F. Bennett, S. T. Crooke, J. Biol. Chem. 262, 13789 (1987). PubMed ID: 2820980

Source:PLCG1Type of molecule:PtdInsKinase Location:FAC
Target:RICSType of molecule:GAP Location:FACA
Type of interaction:Binding Effect:0
References:
1. S. Y. Moon, H. Zang, Y. Zheng, J. Biol. Chem. 278, 4151 (2003). PubMed ID: 12454018

Source:PLCG1Type of molecule:PtdInsKinase Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. N. Perskvist, L. Zheng, O. Stendahl, J. Immunol. 164, 959 (2000). PubMed ID: 10623845

Source:PLCG1Type of molecule:PtdInsKinase Location:FAC
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. C. Pearce, O. J. McCarty, S. D. Calaminus, et al., Biochem. J. 401, 753 (2007). PubMed ID: 17054426

Source:PLCG1Type of molecule:PtdInsKinase Location:FAC
Target:SOS1Type of molecule:RasGEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. M. J. Kim, J. S. Chang, S. K. Park, et al., Biochemistry. 39, 8674 (2000). PubMed ID: 10913276

Source:PLCG1Type of molecule:PtdInsKinase Location:FAC
Target:IP3Type of molecule:Lipid Location:FACA
Type of interaction:Activation Effect:+
References:
1. G. Carpenter, Q. Ji, Exp. Cell. Res. 253, 15 (1999). PubMed ID: 10579907

Source:PLCG1Type of molecule:PtdInsKinase Location:FAC
Target:DAGType of molecule:Lipid Location:FACA
Type of interaction:Activation Effect:+
References:
1. G. Carpenter, Q. Ji, Exp. Cell. Res. 253, 15 (1999). PubMed ID: 10579907

Source:PLCG1Type of molecule:PtdInsKinase Location:FAC
Target:GNB2L1Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. H. Disatnik, S. M. Hernandez-Sotomayor, G. Jones, et al., Proc. Natl. Acad. Sci. U. S. A. 91, 559 (1994). PubMed ID: 8290562

Source:RHOAType of molecule:GTPase Location:FACA
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. K. Thodeti, R. Massoumi, L. Bindslev, et al., Biochem. J. 365, 157 (2002). PubMed ID: 12071848

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. F. Liao, H. S. Shin, S. G. Rhee, Biochem. Biophys. Res. Commun. 191, 1028 (1993). PubMed ID: 7682059

Source:SYKType of molecule:TyrKinase Location:FACA
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. L. Law, K. A. Chandran, S. P. Sidorenko, et al., Mol. Cell. Biol. 16, 1305 (1996). PubMed ID: 8657103