Focal Adhesion Network Components

PIP3

List of interactions:

Source:PIK3CAType of molecule:PtdInsKinase Location:FACA
Target:PIP3Type of molecule:Lipid Location:FACA
Type of interaction:Activation Effect:+
References:
1. M. P. Czech, Cell. 100, 603 (2000). PubMed ID: 10761925

Source:PIP3Type of molecule:Lipid Location:FACA
Target:AKT1Type of molecule:SerThrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. A. Didichenko, B. Tilton, B. A. Hemmings, et al., Curr. Biol. 6, 1271 (1997). PubMed ID: 8939574

Source:PIP3Type of molecule:Lipid Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. S. Singh, A. Chauhan, H. Brockerhoff, et al., Biochem. Biophys. Res. Commun. 195, 104 (1993). PubMed ID: 8395820

Source:PIP3Type of molecule:Lipid Location:FACA
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. Frank, H. Keilhack, F. Opitz, et al., Biochemistry. 38, 11993 (1999). PubMed ID: 10508402

Source:PIP3Type of molecule:Lipid Location:FACA
Target:ILKType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. Dedhar, Curr. Opin. Cell. Biol. 12, 250 (2000). PubMed ID: 10712922

Source:PTENType of molecule:PtdInsPhosphatase Location:FACA
Target:PIP3Type of molecule:Lipid Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. T. Maehama, J. E. Dixon, J. Biol. Chem. 273, 13375 (1998). PubMed ID: 9593664

Source:INPP5DType of molecule:PtdInsPhosphatase Location:FAC
Target:PIP3Type of molecule:Lipid Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. M. D. Ware, P. Rosten, J. E. Damen, et al., Blood. 88, 2833 (1996). PubMed ID: 8874179

Source:INPPL1Type of molecule:PtdInsPhosphatase Location:FAC
Target:PIP3Type of molecule:Lipid Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. X. Pesesse, C. Moreau, A. L. Drayer, et al., FEBS. Lett. 437, 301 (1998). PubMed ID: 9824312