Focal Adhesion Network Components

PIP2

List of interactions:

Source:PIK3CAType of molecule:PtdInsKinase Location:FACA
Target:PIP2Type of molecule:Lipid Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. M. P. Czech, Cell. 100, 603 (2000). PubMed ID: 10761925

Source:PIP2Type of molecule:Lipid Location:FACA
Target:VIL2Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. Hirao, N. Sato, T. Kondo, et al., J. Cell. Biol. 135, 37 (1996). PubMed ID: 8858161

Source:PIP2Type of molecule:Lipid Location:FACA
Target:FLNAType of molecule:ActinBinding Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. K. Furuhashi, M. Inagaki, S. Hatano, et al., Biochem. Biophys. Res. Commun. 184, 1261 (1992). PubMed ID: 1317169

Source:PIP2Type of molecule:Lipid Location:FACA
Target:PFN1Type of molecule:ActinBinding Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. I. Lassing, U. Lindberg, J. Cell. Biochem. 37, 255 (1988). PubMed ID: 2842351

Source:PIP2Type of molecule:Lipid Location:FACA
Target:SDC4Type of molecule:Adhesion Location:FAC
Type of interaction:Activation Effect:+
References:
1. D. Lee, E. S. Oh, A. Woods, et al., J. Biol. Chem. 273, 13022 (1998). PubMed ID: 9582338

Source:PIP2Type of molecule:Lipid Location:FACA
Target:SDCBPType of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. P. Zimmermann, K. Meerschaert, G. Reekmans, et al., Mol. Cell. 9, 1215 (2002). PubMed ID: 12086619

Source:PIP2Type of molecule:Lipid Location:FACA
Target:TLN1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. V. Martel, C. Racaud-Sultan, S. Dupe, et al., J. Biol. Chem. 276, 21217 (2001). PubMed ID: 11279249

Source:PIP2Type of molecule:Lipid Location:FACA
Target:TIAM1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. I. N. Fleming, I. H. Batty, A. R. Prescott, et al., Biochem. J. 382, 857 (2004). PubMed ID: 15242348

Source:PIP2Type of molecule:Lipid Location:FACA
Target:VCLType of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. A. P. Gilmore, K. Burridge, Nature. 381, 531 (1996). PubMed ID: 8632828

Source:PIP2Type of molecule:Lipid Location:FACA
Target:DDEF1Type of molecule:GAP Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. T. Brown, J. Andrade, H. Radhakrishna, et al., Mol. Cell. Biol. 18, 7038 (1998). PubMed ID: 9819391

Source:PIP2Type of molecule:Lipid Location:FACA
Target:PLD1Type of molecule:Phospholipase Location:FACA
Type of interaction:Activation Effect:+
References:
1. M. Liscovitch, V. Chalifa, P. Pertile, et al., J. Biol. Chem. 269, 21403 (1994). PubMed ID: 8063770

Source:PIP2Type of molecule:Lipid Location:FACA
Target:ACTN1Type of molecule:Actinbundling Location:FAC
Type of interaction:Activation Effect:+
References:
1. K. Fukami, T. Endo, M. Imamura, et al., J. Biol. Chem. 269, 1518 (1994). PubMed ID: 8288618

Source:PIP5K1CType of molecule:PtdInsKinase Location:FACA
Target:PIP2Type of molecule:Lipid Location:FACA
Type of interaction:Activation Effect:+
References:
1. M. P. Czech, Cell. 100, 603 (2000). PubMed ID: 10761925