Focal Adhesion Network Components

PIK3CA

Swiss-Prot Human Accession Code: P42336
List of interactions:

Source:ADAM12Type of molecule:Metalloproteinase Location:FACA
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. Q. Kang, Y. Cao, A. Zolkiewska, J. Biol. Chem. 276, 24466 (2001). PubMed ID: 11313349

Source:BCAR3Type of molecule:GEF Location:FACA
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. N. Felekkis, R. P. Narsimhan, R. Near, et al., Mol. Cancer. Res. 3, 32 (2005). PubMed ID: 15671247

Source:BCAR1Type of molecule:Cytoskeletal Location:FAC
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. E. Li, D. G. Stupack, S. L. Brown, et al., J. Biol. Chem. 275, 14729 (2000). PubMed ID: 10799562

Source:CBLType of molecule:E3ligase Location:FACA
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. D. Hartley, H. Meisner, S. Corvera, J. Biol. Chem. 270, 18260 (1995). PubMed ID: 7629144

Source:SH3KBP1Type of molecule:Adapter Location:FAC
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. M. H. Schmidt, B. Chen, L. M. Randazzo, et al., J. Cell. Sci. 116, 2845 (2003). PubMed ID: 12771190

Source:VIL2Type of molecule:Cytoskeletal Location:FAC
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Gautreau, P. Poullet, D. Louvard, et al., Proc. Natl. Acad. Sci. U. S. A. 96, 7300 (1999). PubMed ID: 10377409

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. C. Guinebault, B. Payrastre, C. Racaud-Sultan, et al., J. Cell. Biol. 129, 831 (1995). PubMed ID: 7537275

Source:FYNType of molecule:TyrKinase Location:FACA
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. I. Gout, R. Dhand, G. Panayotou, et al., Biochem. J. 288, 395 (1993). PubMed ID: 1334406

Source:GAB1Type of molecule:Adaptor Location:FAC
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. C. Lecoq-Lafon, F. Verdier, S. Fichelson, et al., Blood. 93, 2578 (1999). PubMed ID: 10194437

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. J. Wang, K. R. Auger, L. Jarvis, et al., J. Biol. Chem. 270, 12774 (1995). PubMed ID: 7759531

Source:HRASType of molecule:GTPase Location:FACA
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. P. Rodriguez-Viciana, P. H. Warne, A. Khwaja, et al., Cell. 89, 457 (1997). PubMed ID: 9150145

Source:INSRType of molecule:Receptor Location:FACA
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. H. Hayashi, Y. Nishioka, S. Kamohara, et al., J. Biol. Chem. 268, 7107 (1993). PubMed ID: 8385099

Source:LYNType of molecule:TyrKinase Location:FACA
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Pigazzi, S. Heydrick, F. Folli, et al., J. Biol. Chem. 274, 14368 (1999). PubMed ID: 10318860

Source:PIK3CAType of molecule:PtdInsKinase Location:FACA
Target:PIP2Type of molecule:Lipid Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. M. P. Czech, Cell. 100, 603 (2000). PubMed ID: 10761925

Source:PIK3CAType of molecule:PtdInsKinase Location:FACA
Target:PIP3Type of molecule:Lipid Location:FACA
Type of interaction:Activation Effect:+
References:
1. M. P. Czech, Cell. 100, 603 (2000). PubMed ID: 10761925

Source:PIK3CAType of molecule:PtdInsKinase Location:FACA
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. K. Koziak, E. Kaczmarek, S. Y. Park, et al., Br. J. Haematol. 114, 134 (2001). PubMed ID: 11472358

Source:PIK3CAType of molecule:PtdInsKinase Location:FACA
Target:PTPRAType of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Stetak, P. Csermely, A. Ullrich, et al., Biochem. Biophys. Res. Commun. 288, 564 (2001). PubMed ID: 11676480

Source:PIK3CAType of molecule:PtdInsKinase Location:FACA
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. et al., Cell. Signal. 10, 407 (1998). PubMed ID: 9720763

Source:PIK3CAType of molecule:PtdInsKinase Location:FACA
Target:TNS1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. K. R. Auger, Z. Songyang, S. H. Lo, et al., J. Biol. Chem. 271, 23452 (1996). PubMed ID: 8798552

Source:PIK3CAType of molecule:PtdInsKinase Location:FACA
Target:KALPHA1Type of molecule:Cytoskeletal Location:FACA
Type of interaction:Binding Effect:0
References:
1. K. Inukai, M. Funaki, M. Nawano, et al., Biochem. J. 346, 483 (2000). PubMed ID: 10677370

Source:PIK3CAType of molecule:PtdInsKinase Location:FACA
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. V. Bertagnolo, M. Marchisio, S. Volinia, et al., FEBS. Lett. 441, 480 (1999). PubMed ID: 9891995

Source:SRCType of molecule:TyrKinase Location:FAC
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. A. Arcaro, M. Aubert, D. e. l. Espinosa, et al., Cell. Signal. (2007). PubMed ID: 17275257