Focal Adhesion Network Components

PAK1

Swiss-Prot Human Accession Code: Q13153
List of interactions:

Source:ABI1Type of molecule:Adapter Location:FACA
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. Y. Ichigotani, S. Yokozaki, Y. Fukuda, et al., Cancer. Res. 62, 2215 (2002). PubMed ID: 11956071

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. J. Roig, P. T. Tuazon, P. A. Zipfel, et al., Proc. Natl. Acad. Sci. U. S. A. 97, 14346 (2001). PubMed ID: 11121037

Source:ACTBType of molecule:Cytoskeletal Location:FAC
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. Dharmawardhane, L. C. Sanders, S. S. Martin, et al., J. Cell. Biol. 138, 1265 (1997). PubMed ID: 9298982

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. G. L. Zhou, Y. Zhuo, C. C. King, et al., Mol. Cell. Biol. 23, 8058 (2003). PubMed ID: 14585966

Source:BCAR3Type of molecule:GEF Location:FACA
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. D. Cai, A. Iyer, K. N. Felekkis, et al., Cancer. Res. 63, 6802 (2003). PubMed ID: 14583477

Source:MAPK1Type of molecule:SerThrKinase Location:FACA
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. L. J. Sundberg-Smith, J. T. Doherty, C. P. Mack, et al., J. Biol. Chem. 280, 2055 (2005). PubMed ID: 15542607

Source:FLNAType of molecule:ActinBinding Location:FAC
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. K. Vadlamudi, F. Li, L. Adam, et al., Nat. Cell. Biol. 4, 681 (2002). PubMed ID: 12198493

Source:GIT1Type of molecule:GAP Location:FAC
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. C. Brown, K. A. West, C. E. Turner, Mol. Biol. Cell. 13, 1550 (2002). PubMed ID: 12006652

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. L. A. Puto, K. Pestonjamasp, C. C. King, et al., J. Biol. Chem. 278, 9388 (2003). PubMed ID: 12522133

Source:NF2Type of molecule:Cytoskeletal Location:FAC
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. J. L. Kissil, E. W. Wilker, K. C. Johnson, et al., Mol. Cell. 12, 841 (2003). PubMed ID: 14580336

Source:NCK2Type of molecule:Adapter Location:FAC
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. C. A. Cowan, M. Henkemeyer, Nature. 413, 174 (2001). PubMed ID: 11557983

Source:PAK1Type of molecule:SerThrKinase Location:FAC
Target:CTTNType of molecule:Actinbinding Location:FAC
Type of interaction:Activation Effect:+
References:
1. B. A. Webb, S. Zhou, R. Eves, et al., Arch. Biochem. Biophys. 456, 183 (2006). PubMed ID: 16854367

Source:PAK1Type of molecule:SerThrKinase Location:FAC
Target:ABL1Type of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. J. Roig, P. T. Tuazon, P. A. Zipfel, et al., Proc. Natl. Acad. Sci. U. S. A. 97, 14346 (2001). PubMed ID: 11121037

Source:PAK1Type of molecule:SerThrKinase Location:FAC
Target:LIMK1Type of molecule:SerThrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. D. C. Edwards, L. C. Sanders, G. M. Bokoch, et al., Nat. Cell. Biol. 1, 253 (1999). PubMed ID: 10559936

Source:PAK1Type of molecule:SerThrKinase Location:FAC
Target:ARHGEF6Type of molecule:GEF Location:FAC
Type of interaction:Binding Effect:0
References:
1. E. Manser, T. H. Loo, C. G. Koh, et al., Mol. Cell. 1, 183 (1998). PubMed ID: 9659915

Source:PAK1Type of molecule:SerThrKinase Location:FAC
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. K. S. Shin, E. Y. Shin, C. S. Lee, et al., Exp. Mol. Med. 34, 172 (2002). PubMed ID: 12085993

Source:PAK1Type of molecule:SerThrKinase Location:FAC
Target:VIMType of molecule:Cytoskeletal Location:FACA
Type of interaction:Activation Effect:+
References:
1. H. Goto, K. Tanabe, E. Manser, et al., Genes. Cells. 7, 91 (2002). PubMed ID: 11895474

Source:PDPK1Type of molecule:SerThrKinase Location:FAC
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. C. King, E. M. Gardiner, F. T. Zenke, et al., J. Biol. Chem. 275, 41201 (2001). PubMed ID: 10995762

Source:PPM1MType of molecule:SerThrPhosphatase Location:FAC
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. C. G. Koh, E. J. Tan, E. Manser, et al., Curr. Biol. 12, 317 (2002). PubMed ID: 11864573

Source:RAC1Type of molecule:GTPase Location:FACA
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. W. Lu, B. J. Mayer, Oncogene. 18, 797 (1999). PubMed ID: 9989831