Focal Adhesion Network Components

LYN

Swiss-Prot Human Accession Code: P07948
List of interactions:

Source:BCAR1Type of molecule:Cytoskeletal Location:FAC
Target:LYNType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. W. Qiu, R. R. Cobb, W. Scholz, J. Leukoc. Biol. 63, 631 (1998). PubMed ID: 9581808

Source:CSKType of molecule:TyrKinase Location:FAC
Target:LYNType of molecule:TyrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. H. C. Cheng, J. D. Bjorge, R. Aebersold, et al., Biochemistry. 35, 11874 (1996). PubMed ID: 8794770

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:LYNType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. I. Mlinaric-Rascan, T. Yamamoto, FEBS. Lett. 498, 26 (2001). PubMed ID: 11389892

Source:LYNType of molecule:TyrKinase Location:FACA
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Activation Effect:+
References:
1. L. Wang, W. A. Rudert, I. Loutaev, et al., Oncogene. 21, 5346 (2002). PubMed ID: 12149655

Source:LYNType of molecule:TyrKinase Location:FACA
Target:NEDD9Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. N. Manie, A. R. Beck, A. Astier, et al., J. Biol. Chem. 272, 4230 (1997). PubMed ID: 9020138

Source:LYNType of molecule:TyrKinase Location:FACA
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Pigazzi, S. Heydrick, F. Folli, et al., J. Biol. Chem. 274, 14368 (1999). PubMed ID: 10318860

Source:LYNType of molecule:TyrKinase Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. A. Pace, J. A. Tapia, L. J. Garcia-Marin, et al., Biochim. Biophys. Acta. 1763, 356 (2006). PubMed ID: 16713446

Source:LYNType of molecule:TyrKinase Location:FACA
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. M. Pleiman, M. R. Clark, L. K. Gauen, et al., Mol. Cell. Biol. 13, 5877 (1993). PubMed ID: 8395016

Source:LYNType of molecule:TyrKinase Location:FACA
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Yamasaki, H. Arai, N. Ashida, et al., Biochem. J. 355, 751 (2001). PubMed ID: 11311138

Source:LYNType of molecule:TyrKinase Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Ptasznik, A. Traynor-Kaplan, G. M. Bokoch, J. Biol. Chem. 270, 19969 (1995). PubMed ID: 7650013

Source:LYNType of molecule:TyrKinase Location:FACA
Target:INPP5DType of molecule:PtdInsPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. C. P. Baran, S. Tridandapani, C. D. Helgason, et al., J. Biol. Chem. 278, 38628 (2003). PubMed ID: 12882960

Source:LYNType of molecule:TyrKinase Location:FACA
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. K. Yoshida, S. Kharbanda, D. Kufe, J. Biol. Chem. 274, 34663 (2000). PubMed ID: 10574931

Source:LYNType of molecule:TyrKinase Location:FACA
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. P. Sidorenko, C. L. Law, K. A. Chandran, et al., Proc. Natl. Acad. Sci. U. S. A. 92, 359 (1995). PubMed ID: 7831290

Source:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Target:LYNType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. K. Yoshida, S. Kharbanda, D. Kufe, J. Biol. Chem. 274, 34663 (2000). PubMed ID: 10574931