Focal Adhesion Network Components

IRS1

Swiss-Prot Human Accession Code: P35568
List of interactions:

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. Paz, Y. F. Liu, H. Shorer, et al., J. Biol. Chem. 274, 28816 (1999). PubMed ID: 10497255

Source:CSKType of molecule:TyrKinase Location:FAC
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. Tobe, H. Sabe, T. Yamamoto, et al., Mol. Cell. Biol. 16, 4765 (1996). PubMed ID: 8756634

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. S. Manes, E. Mira, C. Gomez-Mouton, et al., Mol. Cell. Biol. 19, 3125 (1999). PubMed ID: 10082579

Source:GRB2Type of molecule:Adapter Location:FAC
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. E. Y. Skolnik, C. H. Lee, A. Batzer, et al., EMBO. J. 12, 1929 (1993). PubMed ID: 8491186

Source:INSRType of molecule:Receptor Location:FACA
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. V. Aguirre, E. D. Werner, J. Giraud, et al., J. Biol. Chem. 277, 1531 (2002). PubMed ID: 11606564

Source:IRS1Type of molecule:Adapter Location:FACA
Target:NCK2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. Y. Tu, F. Li, C. Wu, Mol. Biol. Cell. 9, 3367 (1999). PubMed ID: 9843575

Source:IRS1Type of molecule:Adapter Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. Nawaratne, A. Gray, C. H. Jorgensen, et al., Mol. Endocrinol. 20, 1838 (2006). PubMed ID: 16574739

Source:IRS1Type of molecule:Adapter Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Kasus-Jacobi, D. Perdereau, S. Tartare-Deckert, et al., J. Biol. Chem. 272, 17166 (1997). PubMed ID: 9202037

Source:MAPK8Type of molecule:SerThrKinase Location:FACA
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. V. Aguirre, T. Uchida, L. Yenush, et al., J. Biol. Chem. 275, 9047 (2000). PubMed ID: 10722755

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. Y. Li, T. J. Soos, X. Li, et al., J. Biol. Chem. 279, 45304 (2004). PubMed ID: 15364919

Source:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. B. J. Goldstein, A. Bittner-Kowalczyk, M. F. White, et al., J. Biol. Chem. 275, 4283 (2000). PubMed ID: 10660596

Source:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. S. Tanaka, L. Mohr, E. V. Schmidt, et al., Hepatology. 26, 598 (1997). PubMed ID: 9303488