Focal Adhesion Network Components

INSR

Swiss-Prot Human Accession Code: P06213
List of interactions:

Source:CAV1Type of molecule:Cytoskeletal Location:FAC
Target:INSRType of molecule:Receptor Location:FACA
Type of interaction:Binding Effect:0
References:
1. M. Yamamoto, Y. Toya, C. Schwencke, et al., J. Biol. Chem. 273, 26962 (1998). PubMed ID: 9756945

Source:CSKType of molecule:TyrKinase Location:FAC
Target:INSRType of molecule:Receptor Location:FACA
Type of interaction:Binding Effect:0
References:
1. C. Arbet-Engels, S. Tartare-Deckert, W. Eckhart, J. Biol. Chem. 274, 5422 (1999). PubMed ID: 10026153

Source:GRB7Type of molecule:Adapter Location:FAC
Target:INSRType of molecule:Receptor Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Kasus-Jacobi, V. Bereziat, D. Perdereau, et al., Oncogene. 19, 2052 (2000). PubMed ID: 10803466

Source:HRASType of molecule:GTPase Location:FACA
Target:INSRType of molecule:Receptor Location:FACA
Type of interaction:Binding Effect:0
References:
1. R. M. O'Brien, K. Siddle, M. D. Houslay, et al., FEBS. Lett. 217, 253 (1987). PubMed ID: 3109943

Source:INSRType of molecule:Receptor Location:FACA
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Activation Effect:+
References:
1. J. Liu, A. Kimura, C. A. Baumann, et al., Mol. Cell. Biol. 22, 3599 (2002). PubMed ID: 11997497

Source:INSRType of molecule:Receptor Location:FACA
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. V. Baron, V. Calleja, P. Ferrari, et al., J. Biol. Chem. 273, 7162 (1998). PubMed ID: 9507031

Source:INSRType of molecule:Receptor Location:FACA
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. V. Aguirre, E. D. Werner, J. Giraud, et al., J. Biol. Chem. 277, 1531 (2002). PubMed ID: 11606564

Source:INSRType of molecule:Receptor Location:FACA
Target:RASA1Type of molecule:GAP Location:FAC
Type of interaction:Activation Effect:+
References:
1. G. J. Pronk, R. H. Medema, B. M. Burgering, et al., J. Biol. Chem. 267, 24058 (1992). PubMed ID: 1331107

Source:INSRType of molecule:Receptor Location:FACA
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. H. Hayashi, Y. Nishioka, S. Kamohara, et al., J. Biol. Chem. 268, 7107 (1993). PubMed ID: 8385099

Source:INSRType of molecule:Receptor Location:FACA
Target:SORBS1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. V. Ribon, J. A. Printen, N. G. Hoffman, et al., Mol. Cell. Biol. 18, 872 (1998). PubMed ID: 9447983

Source:INSRType of molecule:Receptor Location:FACA
Target:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. Dadke, A. Kusari, J. Kusari, Mol. Cell. Biochem. 221, 147 (2001). PubMed ID: 11506178

Source:INSRType of molecule:Receptor Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. S. Kovacina, R. A. Roth, Biochem. Biophys. Res. Commun. 192, 1303 (1993). PubMed ID: 7685165

Source:INSRType of molecule:Receptor Location:FACA
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. T. Uchida, T. Matozaki, T. Noguchi, et al., J. Biol. Chem. 269, 12220 (1994). PubMed ID: 7512963

Source:INSRType of molecule:Receptor Location:FACA
Target:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. H. Maegawa, S. Ugi, M. Adachi, et al., Biochem. Biophys. Res. Commun. 199, 780 (1994). PubMed ID: 8135823

Source:INSRType of molecule:Receptor Location:FACA
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. Uddin, S. Katzav, M. F. White, et al., J. Biol. Chem. 270, 7712 (1995). PubMed ID: 7535775

Source:INSRType of molecule:Receptor Location:FACA
Target:GAB1Type of molecule:Adaptor Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. Lehr, J. Kotzka, A. Herkner, et al., Biochemistry. 39, 10898 (2000). PubMed ID: 10978177

Source:PTPRFType of molecule:TyrPhosphatase Location:FAC
Target:INSRType of molecule:Receptor Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. K. Tsujikawa, N. Kawakami, Y. Uchino, et al., Mol. Endocrinol. 15, 271 (2001). PubMed ID: 11158333

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:INSRType of molecule:Receptor Location:FACA
Type of interaction:Activation Effect:+
References:
1. J. Ahn, D. B. Donner, O. M. Rosen, J. Biol. Chem. 268, 7571 (1993). PubMed ID: 8463287

Source:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Target:INSRType of molecule:Receptor Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. X. Espanel, M. Huguenin-Reggiani, Protein. Sci. 11, 2326 (2002). PubMed ID: 12237455