Focal Adhesion Network Components

HRAS

Swiss-Prot Human Accession Code: P01112
List of interactions:

Source:HRASType of molecule:GTPase Location:FACA
Target:INSRType of molecule:Receptor Location:FACA
Type of interaction:Binding Effect:0
References:
1. R. M. O'Brien, K. Siddle, M. D. Houslay, et al., FEBS. Lett. 217, 253 (1987). PubMed ID: 3109943

Source:HRASType of molecule:GTPase Location:FACA
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. P. Rodriguez-Viciana, P. H. Warne, A. Khwaja, et al., Cell. 89, 457 (1997). PubMed ID: 9150145

Source:HRASType of molecule:GTPase Location:FACA
Target:TIAM1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. J. Yamauchi, Y. Miyamoto, A. Tanoue, et al., Proc. Natl. Acad. Sci. U. S. A. 102, 14889 (2005). PubMed ID: 16203995

Source:RASA1Type of molecule:GAP Location:FAC
Target:HRASType of molecule:GTPase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. D. P. Molloy, D. Owen, R. J. Grand, FEBS. Lett. 368, 297 (1995). PubMed ID: 7628625

Source:SOS1Type of molecule:RasGEF Location:FACA
Target:HRASType of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. P. A. Boriack-Sjodin, S. M. Margarit, D. Bar-Sagi, et al., Nature. 394, 337 (1998). PubMed ID: 9690470

Source:VAV1Type of molecule:GEF Location:FACA
Target:HRASType of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. E. Gulbins, K. M. Coggeshall, C. Langlet, et al., Mol. Cell. Biol. 14, 906 (1994). PubMed ID: 8289830