Focal Adhesion Network Components

GRB2

Swiss-Prot Human Accession Code: P62993
List of interactions:

Source:ADAM12Type of molecule:Metalloproteinase Location:FACA
Target:GRB2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Suzuki, N. Kadota, T. Hara, et al., Oncogene. 19, 5842 (2000). PubMed ID: 11127814

Source:JUBType of molecule:Cytoskeletal Location:FAC
Target:GRB2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. K. Goyal, P. Lin, J. Kanungo, et al., Mol. Cell. Biol. 19, 4379 (1999). PubMed ID: 10330178

Source:RAPGEF1Type of molecule:GEF Location:FACA
Target:GRB2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. Tanaka, T. Morishita, Y. Hashimoto, et al., Proc. Natl. Acad. Sci. U. S. A. 91, 3443 (1994). PubMed ID: 7512734

Source:CBLType of molecule:E3ligase Location:FACA
Target:GRB2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. K. Park, W. T. Kyono, Y. Liu, et al., J. Immunol. 160, 5018 (1998). PubMed ID: 9590251

Source:SH3KBP1Type of molecule:Adapter Location:FAC
Target:GRB2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. C. Borinstein, M. A. Hyatt, V. W. Sykes, et al., Cell. Signal. 12, 769 (2001). PubMed ID: 11152963

Source:CRKType of molecule:Cytoskeletal Location:FAC
Target:GRB2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. Ren, Z. S. Ye, D. Baltimore, Genes. Dev. 8, 783 (1994). PubMed ID: 7926767

Source:DNM2Type of molecule:GTPase Location:FAC
Target:GRB2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Ando, K. Yonezawa, I. Gout, et al., EMBO. J. 13, 3033 (1994). PubMed ID: 8039498

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:GRB2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. D. D. Schlaepfer, S. K. Hanks, T. Hunter, et al., Nature. 372, 786 (1995). PubMed ID: 7997267

Source:GAB1Type of molecule:Adaptor Location:FAC
Target:GRB2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Holgado-Madruga, D. R. Emlet, D. K. Moscatello, et al., Nature. 379, 560 (1996). PubMed ID: 8596638

Source:GRB2Type of molecule:Adapter Location:FAC
Target:KALPHA1Type of molecule:Cytoskeletal Location:FACA
Type of interaction:Binding Effect:0
References:
1. T. Itoh, K. Miura, H. Miki, et al., J. Biol. Chem. 271, 27931 (1996). PubMed ID: 8910394

Source:GRB2Type of molecule:Adapter Location:FAC
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. E. Y. Skolnik, C. H. Lee, A. Batzer, et al., EMBO. J. 12, 1929 (1993). PubMed ID: 8491186

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. L. A. Puto, K. Pestonjamasp, C. C. King, et al., J. Biol. Chem. 278, 9388 (2003). PubMed ID: 12522133

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. J. Wang, K. R. Auger, L. Jarvis, et al., J. Biol. Chem. 270, 12774 (1995). PubMed ID: 7759531

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. Z. Pei, J. A. Maloney, L. Yang, et al., Arch. Biochem. Biophys. 345, 103 (1997). PubMed ID: 9281317

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Type of interaction:Binding Effect:0
References:
1. B. J. Goldstein, A. Bittner-Kowalczyk, M. F. White, et al., J. Biol. Chem. 275, 4283 (2000). PubMed ID: 10660596

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Charest, J. Wagner, M. Kwan, et al., Oncogene. 14, 1643 (1997). PubMed ID: 9135065

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. T. Ohmori, Y. Yatomi, N. Asazuma, et al., Biochem. J. 347, 561 (2001). PubMed ID: 10749687

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PTPRAType of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. EMBO. J. 13, 3020 (1994). PubMed ID: 7518772

Source:GRB2Type of molecule:Adapter Location:FAC
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. E. Y. Skolnik, C. H. Lee, A. Batzer, et al., EMBO. J. 12, 1929 (1993). PubMed ID: 8491186

Source:GRB2Type of molecule:Adapter Location:FAC
Target:INPP5DType of molecule:PtdInsPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. J. M. Mason, B. K. Beattie, Q. Liu, et al., J. Biol. Chem. 275, 4398 (2000). PubMed ID: 10660611

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. P. Minoo, M. M. Zadeh, R. Rottapel, et al., Blood. 103, 1398 (2004). PubMed ID: 14551136

Source:GRB2Type of molecule:Adapter Location:FAC
Target:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. L. Wong, G. R. Johnson, J. Biol. Chem. 271, 20981 (1996). PubMed ID: 8702859

Source:GRB2Type of molecule:Adapter Location:FAC
Target:SOS1Type of molecule:RasGEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. P. Chardin, J. H. Camonis, N. W. Gale, et al., Science. 260, 1338 (1993). PubMed ID: 8493579

Source:GRB2Type of molecule:Adapter Location:FAC
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Saci, W. Q. Liu, M. Vidal, et al., Biochem. J. 363, 717 (2002). PubMed ID: 11964172

Source:GRB2Type of molecule:Adapter Location:FAC
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. I. S. Lee, Y. Liu, M. Narazaki, et al., FEBS. Lett. 401, 133 (1997). PubMed ID: 9013873

Source:SRCType of molecule:TyrKinase Location:FAC
Target:GRB2Type of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. D. A. Jones, C. W. Benjamin, Arch. Biochem. Biophys. 337, 143 (1997). PubMed ID: 9016807