Focal Adhesion Network Components

GIT1

Swiss-Prot Human Accession Code: Q9Y2X7
List of interactions:

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:GIT1Type of molecule:GAP Location:FAC
Type of interaction:Activation Effect:+
References:
1. Z. S. Zhao, E. Manser, T. H. Loo, et al., Mol. Cell. Biol. 20, 6354 (2000). PubMed ID: 10938112

Source:GIT1Type of molecule:GAP Location:FAC
Target:ARF1Type of molecule:GTPase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. R. T. Premont, A. Claing, N. Vitale, et al., J. Biol. Chem. 275, 22373 (2000). PubMed ID: 10896954

Source:GIT1Type of molecule:GAP Location:FAC
Target:TGFB1I1Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. N. Nishiya, T. Shirai, W. Suzuki, et al., J. Biochem. (Tokyo). 132, 279 (2002). PubMed ID: 12153727

Source:GIT1Type of molecule:GAP Location:FAC
Target:LPXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Gupta, B. S. Lee, M. A. Khadeer, et al., J. Bone. Miner. Res. 18, 669 (2003). PubMed ID: 12674328

Source:GIT1Type of molecule:GAP Location:FAC
Target:PPFIA1Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. J. Ko, S. Kim, J. G. Valtschanoff, et al., J. Neurosci. 23, 1667 (2003). PubMed ID: 12629171

Source:GIT1Type of molecule:GAP Location:FAC
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. C. Brown, K. A. West, C. E. Turner, Mol. Biol. Cell. 13, 1550 (2002). PubMed ID: 12006652

Source:GIT1Type of molecule:GAP Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. K. A. West, H. Zhang, M. C. Brown, et al., J. Cell. Biol. 154, 161 (2001). PubMed ID: 11448998

Source:GIT1Type of molecule:GAP Location:FAC
Target:ARHGEF6Type of molecule:GEF Location:FAC
Type of interaction:Binding Effect:0
References:
1. O. A. Botrugno, S. Paris, L. Za, et al., Eur. J. Cell. Biol. 85, 35 (2005). PubMed ID: 16373173

Source:GIT1Type of molecule:GAP Location:FAC
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. J. Hoefen, B. C. Berk, J. Cell. Sci. 119, 1469 (2006). PubMed ID: 16598076

Source:GIT1Type of molecule:GAP Location:FAC
Target:MAPK1Type of molecule:SerThrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. G. Yin, Q. Zheng, C. Yan, et al., J. Biol. Chem. 280, 27705 (2005). PubMed ID: 15923189

Source:SRCType of molecule:TyrKinase Location:FAC
Target:GIT1Type of molecule:GAP Location:FAC
Type of interaction:Activation Effect:+
References:
1. J. Haendeler, G. Yin, Y. Hojo, et al., J. Biol. Chem. 278, 49936 (2003). PubMed ID: 14523024