Focal Adhesion Network Components

FYN

Swiss-Prot Human Accession Code: P06241
List of interactions:

Source:CSKType of molecule:TyrKinase Location:FAC
Target:FYNType of molecule:TyrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. M. Takeuchi, S. Kuramochi, N. Fusaki, et al., J. Biol. Chem. 268, 27413 (1994). PubMed ID: 8262983

Source:PTK2Type of molecule:TyrKinase Location:FAC
Target:FYNType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. S. T. Arold, T. S. Ulmer, T. D. Mulhern, et al., J. Biol. Chem. 276, 17199 (2001). PubMed ID: 11278857

Source:FYNType of molecule:TyrKinase Location:FACA
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. N. Manie, A. Astier, N. Haghayeghi, et al., J. Biol. Chem. 272, 15636 (1997). PubMed ID: 9188452

Source:FYNType of molecule:TyrKinase Location:FACA
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. Hunter, E. A. Burton, S. C. Wu, et al., J. Biol. Chem. 274, 2097 (1999). PubMed ID: 9890970

Source:FYNType of molecule:TyrKinase Location:FACA
Target:TGFB1I1Type of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. Ishino, H. Aoto, H. Sasaski, et al., FEBS. Lett. 474, 179 (2000). PubMed ID: 10838081

Source:FYNType of molecule:TyrKinase Location:FACA
Target:ITGB1Type of molecule:Adhesion Location:FAC
Type of interaction:Activation Effect:+
References:
1. A. Mariotti, P. A. Kedeshian, M. Dans, et al., J. Cell. Biol. 155, 447 (2001). PubMed ID: 11684709

Source:FYNType of molecule:TyrKinase Location:FACA
Target:PTPRFType of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. K. Tsujikawa, T. Ichijo, K. Moriyama, et al., Mol. Cancer. Res. 1, 155 (2002). PubMed ID: 12496362

Source:FYNType of molecule:TyrKinase Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. M. Thomas, P. Soriano, A. Imamoto, Nature. 376, 267 (1995). PubMed ID: 7617039

Source:FYNType of molecule:TyrKinase Location:FACA
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. I. Gout, R. Dhand, G. Panayotou, et al., Biochem. J. 288, 395 (1993). PubMed ID: 1334406

Source:FYNType of molecule:TyrKinase Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. D. Crosby, A. W. Poole, J. Biol. Chem. 278, 24533 (2003). PubMed ID: 12721299

Source:FYNType of molecule:TyrKinase Location:FACA
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. C. M. Pleiman, M. R. Clark, L. K. Gauen, et al., Mol. Cell. Biol. 13, 5877 (1993). PubMed ID: 8395016

Source:FYNType of molecule:TyrKinase Location:FACA
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. D. Qian, S. Lev, et al., J. Exp. Med. 185, 1253 (1997). PubMed ID: 9104812

Source:FYNType of molecule:TyrKinase Location:FACA
Target:GNB2L1Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. Yaka, C. Thornton, A. J. Vagts, et al., Proc. Natl. Acad. Sci. U. S. A. 99, 5710 (2002). PubMed ID: 11943848

Source:FYNType of molecule:TyrKinase Location:FACA
Target:RICSType of molecule:GAP Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. Taniguchi, H. Liu, T. Nakazawa, et al., Biochem. Biophys. Res. Commun. 306, 151 (2003). PubMed ID: 12788081

Source:FYNType of molecule:TyrKinase Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. K. Wary, A. Mariotti, C. Zurzolo, et al., Cell. 94, 625 (1998). PubMed ID: 9741627

Source:FYNType of molecule:TyrKinase Location:FACA
Target:PTPN11Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. H. Tang, Z. J. Zhao, X. Y. Huang, et al., J. Biol. Chem. 274, 12401 (1999). PubMed ID: 10212213

Source:FYNType of molecule:TyrKinase Location:FACA
Target:SOS1Type of molecule:RasGEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. C. Park, Y. Choi, Y. Yun, Mol. Cells. 8, 518 (1999). PubMed ID: 9856337

Source:FYNType of molecule:TyrKinase Location:FACA
Target:SDC4Type of molecule:Adhesion Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. E. Lauri, S. Kaukinen, T. Kinnunen, et al., J. Neurosci. 19, 1226 (1999). PubMed ID: 9952400

Source:FYNType of molecule:TyrKinase Location:FACA
Target:THY1Type of molecule:Adhesion Location:FACA
Type of interaction:Binding Effect:0
References:
1. P. M. Thomas, L. E. Samelson, J. Biol. Chem. 267, 12317 (1992). PubMed ID: 1351058

Source:FYNType of molecule:TyrKinase Location:FACA
Target:KALPHA1Type of molecule:Cytoskeletal Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. Marie-Cardine, H. Kirchgessner, C. Eckerskorn, et al., Eur. J. Immunol. 25, 3290 (1996). PubMed ID: 8566014

Source:FYNType of molecule:TyrKinase Location:FACA
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Activation Effect:+
References:
1. F. Michel, L. Grimaud, L. Tuosto, et al., J. Biol. Chem. 273, 31932 (1998). PubMed ID: 9822663

Source:FYNType of molecule:TyrKinase Location:FACA
Target:P190GAPType of molecule:NA Location:NA
Type of interaction:Activation Effect:+
References:
1. R. M. Wolf, J. J. Wilkes, M. V. Chao, et al., J. Neurobiol. 49, 62 (2001). PubMed ID: 11536198

Source:PTPRFType of molecule:TyrPhosphatase Location:FAC
Target:FYNType of molecule:TyrKinase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. K. Tsujikawa, T. Ichijo, K. Moriyama, et al., Mol. Cancer. Res. 1, 155 (2002). PubMed ID: 12496362

Source:PTPRAType of molecule:TyrPhosphatase Location:FAC
Target:FYNType of molecule:TyrKinase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. et al., J. Cell. Biol. 161, 143 (2003). PubMed ID: 12682088