Focal Adhesion Network Components

FLNA

Swiss-Prot Human Accession Code: P21333
List of interactions:

Source:ACTBType of molecule:Cytoskeletal Location:FAC
Target:FLNAType of molecule:ActinBinding Location:FAC
Type of interaction:Binding Effect:0
References:
1. K. Wang, S. J. Singer, Proc. Natl. Acad. Sci. U. S. A. 74, 2021 (1977). PubMed ID: 325564

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:FLNAType of molecule:ActinBinding Location:FAC
Type of interaction:Activation Effect:+
References:
1. J. T. Murray, D. G. Campbell, M. Peggie, et al., Biochem. J. 384, 489 (2004). PubMed ID: 15461588

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:FLNAType of molecule:ActinBinding Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. J. R. Guyon, E. Kudryashova, A. Potts, et al., Muscle. Nerve. 28, 472 (2003). PubMed ID: 14506720

Source:CAV1Type of molecule:Cytoskeletal Location:FAC
Target:FLNAType of molecule:ActinBinding Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Stahlhut, Mol. Biol. Cell. 11, 325 (2000). PubMed ID: 10637311

Source:CEACAM1Type of molecule:Adhesion Location:FACA
Target:FLNAType of molecule:ActinBinding Location:FAC
Type of interaction:Binding Effect:0
References:
1. E. Klaile, M. M. Muller, C. Kannicht, et al., J. Cell. Sci. 118, 5513 (2005). PubMed ID: 16291724

Source:FLNAType of molecule:ActinBinding Location:FAC
Target:ITGB1Type of molecule:Adhesion Location:FAC
Type of interaction:Binding Effect:0
References:
1. D. A. Calderwood, A. Huttenlocher, W. B. Kiosses, et al., Nat. Cell. Biol. 3, 1060 (2002). PubMed ID: 11781567

Source:FLNAType of molecule:ActinBinding Location:FAC
Target:FBLIM1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. Y. Tu, S. Wu, X. Shi, et al., Cell. 113, 37 (2003). PubMed ID: 12679033

Source:FLNAType of molecule:ActinBinding Location:FAC
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. K. Vadlamudi, F. Li, L. Adam, et al., Nat. Cell. Biol. 4, 681 (2002). PubMed ID: 12198493

Source:FLNAType of molecule:ActinBinding Location:FAC
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Binding Effect:0
References:
1. J. M. Bellanger, C. Astier, C. Sardet, et al., Nat. Cell. Biol. 2, 888 (2001). PubMed ID: 11146652

Source:FLNAType of molecule:ActinBinding Location:FAC
Target:INPPL1Type of molecule:PtdInsPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. Y. Wang, R. J. Keogh, M. G. Hunter, et al., J. Immunol. 173, 6820 (2004). PubMed ID: 15557176

Source:FLNAType of molecule:ActinBinding Location:FAC
Target:TRIOType of molecule:GEF Location:FACA
Type of interaction:Binding Effect:0
References:
1. J. M. Bellanger, C. Astier, C. Sardet, et al., Nat. Cell. Biol. 2, 888 (2001). PubMed ID: 11146652

Source:FLNAType of molecule:ActinBinding Location:FAC
Target:ROCK1Type of molecule:SerThrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. K. Ueda, Y. Ohta, H. Hosoya, Biochem. Biophys. Res. Commun. 301, 886 (2003). PubMed ID: 12589795

Source:FLNAType of molecule:ActinBinding Location:FAC
Target:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. P. Playford, P. D. Lyons, S. K. Sastry, et al., J. Biol. Chem. 281, 34104 (2006). PubMed ID: 16973606

Source:PIP2Type of molecule:Lipid Location:FACA
Target:FLNAType of molecule:ActinBinding Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. K. Furuhashi, M. Inagaki, S. Hatano, et al., Biochem. Biophys. Res. Commun. 184, 1261 (1992). PubMed ID: 1317169

Source:PRKACAType of molecule:SerThrKinase Location:FACA
Target:FLNAType of molecule:ActinBinding Location:FAC
Type of interaction:Activation Effect:+
References:
1. D. Wallach, P. J. Davies, I. Pastan, J. Biol. Chem. 253, 4739 (1978). PubMed ID: 207708

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:FLNAType of molecule:ActinBinding Location:FAC
Type of interaction:Activation Effect:+
References:
1. U. Tigges, B. Koch, J. Wissing, et al., J. Biol. Chem. 278, 23561 (2003). PubMed ID: 12704190