Focal Adhesion Network Components

CBL

Swiss-Prot Human Accession Code: P22681
List of interactions:

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Activation Effect:+
References:
1. C. E. Andoniou, C. B. Thien, W. Y. Langdon, EMBO. J. 13, 4515 (1994). PubMed ID: 7925293

Source:SORBS2Type of molecule:Adapter Location:FAC
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Binding Effect:0
References:
1. P. Soubeyran, A. Barac, I. Szymkiewicz, et al., Biochem. J. 370, 29 (2003). PubMed ID: 12475393

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. A. Oda, K. Ozaki, B. J. Druker, et al., Blood. 88, 1330 (1996). PubMed ID: 8695851

Source:CBLType of molecule:E3ligase Location:FACA
Target:ITGA5Type of molecule:Adhesion Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. T. Zell, C. S. Warden, A. S. Chan, et al., Curr. Biol. 8, 814 (1998). PubMed ID: 9663390

Source:CBLType of molecule:E3ligase Location:FACA
Target:ABL1Type of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. P. Soubeyran, A. Barac, I. Szymkiewicz, et al., Biochem. J. 370, 29 (2003). PubMed ID: 12475393

Source:CBLType of molecule:E3ligase Location:FACA
Target:SH3KBP1Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. P. Soubeyran, K. Kowanetz, I. Szymkiewicz, et al., Nature. 416, 183 (2002). PubMed ID: 11894095

Source:CBLType of molecule:E3ligase Location:FACA
Target:CRKType of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. V. Ribon, S. Hubbell, R. Herrera, et al., Mol. Cell. Biol. 16, 45 (1996). PubMed ID: 8524328

Source:CBLType of molecule:E3ligase Location:FACA
Target:CRKLType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. M. Sattler, R. Salgia, G. Shrikhande, et al., J. Biol. Chem. 272, 14320 (1997). PubMed ID: 9162067

Source:CBLType of molecule:E3ligase Location:FACA
Target:DNM2Type of molecule:GTPase Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Bruzzaniti, L. Neff, A. Sanjay, et al., Mol. Biol. Cell. 16, 3301 (2005). PubMed ID: 15872089

Source:CBLType of molecule:E3ligase Location:FACA
Target:GRB2Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. K. Park, W. T. Kyono, Y. Liu, et al., J. Immunol. 160, 5018 (1998). PubMed ID: 9590251

Source:CBLType of molecule:E3ligase Location:FACA
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. D. Hartley, H. Meisner, S. Corvera, J. Biol. Chem. 270, 18260 (1995). PubMed ID: 7629144

Source:CBLType of molecule:E3ligase Location:FACA
Target:PLCG1Type of molecule:PtdInsKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. D. Tvorogov, G. Carpenter, Exp. Cell. Res. 277, 86 (2002). PubMed ID: 12061819

Source:CBLType of molecule:E3ligase Location:FACA
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Sanjay, A. Houghton, L. Neff, et al., J. Cell. Biol. 152, 181 (2001). PubMed ID: 11149930

Source:CBLType of molecule:E3ligase Location:FACA
Target:OSTF1Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. I. Szymkiewicz, O. Destaing, P. Jurdic, et al., FEBS. Lett. 565, 33 (2004). PubMed ID: 15135048

Source:CBLType of molecule:E3ligase Location:FACA
Target:SHC1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. G. Panchamoorthy, T. Fukazawa, S. Miyake, et al., J. Biol. Chem. 271, 3187 (1996). PubMed ID: 8621719

Source:CBLType of molecule:E3ligase Location:FACA
Target:INPPL1Type of molecule:PtdInsPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. I. Vandenbroere, N. Paternotte, J. E. Dumont, et al., Biochem. Biophys. Res. Commun. 300, 494 (2002). PubMed ID: 12504111

Source:CBLType of molecule:E3ligase Location:FACA
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. H. Odai, K. Sasaki, Y. Hanazono, et al., Jpn. J. Cancer. Res. 86, 1119 (1996). PubMed ID: 8635998

Source:CBLType of molecule:E3ligase Location:FACA
Target:SYKType of molecule:TyrKinase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. G. Panchamoorthy, T. Fukazawa, S. Miyake, et al., J. Biol. Chem. 271, 3187 (1996). PubMed ID: 8621719

Source:CBLType of molecule:E3ligase Location:FACA
Target:KALPHA1Type of molecule:Cytoskeletal Location:FACA
Type of interaction:Binding Effect:0
References:
1. A. M. Teckchandani, A. A. Birukova, K. Tar, et al., Exp. Cell. Res. 306, 114 (2005). PubMed ID: 15878338

Source:CBLType of molecule:E3ligase Location:FACA
Target:VAV1Type of molecule:GEF Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. A. M. Teckchandani, E. A. Feshchenko, A. Y. Tsygankov, Oncogene. 20, 1739 (2001). PubMed ID: 11313921

Source:FYNType of molecule:TyrKinase Location:FACA
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. Hunter, E. A. Burton, S. C. Wu, et al., J. Biol. Chem. 274, 2097 (1999). PubMed ID: 9890970

Source:INSRType of molecule:Receptor Location:FACA
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Activation Effect:+
References:
1. J. Liu, A. Kimura, C. A. Baumann, et al., Mol. Cell. Biol. 22, 3599 (2002). PubMed ID: 11997497

Source:LYNType of molecule:TyrKinase Location:FACA
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Activation Effect:+
References:
1. L. Wang, W. A. Rudert, I. Loutaev, et al., Oncogene. 21, 5346 (2002). PubMed ID: 12149655

Source:ARHGEF6Type of molecule:GEF Location:FAC
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. J. A. Flanders, Q. Feng, S. Bagrodia, et al., FEBS. Lett. 550, 119 (2003). PubMed ID: 12935897

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Activation Effect:+
References:
1. G. Pedraza-Alva, S. Sawasdikosol, Y. C. Liu, et al., J. Biol. Chem. 276, 729 (2001). PubMed ID: 11024037

Source:SORBS1Type of molecule:Adapter Location:FACA
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Binding Effect:0
References:
1. M. Zhang, A. Kimura, A. R. Saltiel, Mol. Med. 9, 18 (2003). PubMed ID: 12765336

Source:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. R. D. Chernock, R. P. Cherla, R. K. Ganju, Blood. 97, 608 (2001). PubMed ID: 11157475

Source:SYKType of molecule:TyrKinase Location:FACA
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Activation Effect:+
References:
1. M. L. Lupher, R. a. o. Jr,, et al., J. Biol. Chem. 273, 35273 (1999). PubMed ID: 9857068