Focal Adhesion Network Components

CAPN1

Swiss-Prot Human Accession Code: P07384
List of interactions:

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. T. B. Shea, M. L. Beermann, W. R. Griffin, et al., FEBS. Lett. 350, 223 (1994). PubMed ID: 8070569

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:ACTN1Type of molecule:Actinbundling Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. N. Selliah, W. H. Brooks, T. L. Roszman, J. Immunol. 156, 3215 (1996). PubMed ID: 8617943

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:CTTNType of molecule:Actinbinding Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. C. Huang, N. N. Tandon, N. J. Greco, et al., J. Biol. Chem. 272, 19248 (1997). PubMed ID: 9235918

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:VIL2Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. A. Shcherbina, A. Bretscher, D. M. Kenney, et al., FEBS. Lett. 443, 31 (1999). PubMed ID: 9928947

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. P. Cooray, Y. Yuan, S. M. Schoenwaelder, et al., Biochem. J. 318, 41 (1996). PubMed ID: 8761450

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:FLNAType of molecule:ActinBinding Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. J. R. Guyon, E. Kudryashova, A. Potts, et al., Muscle. Nerve. 28, 472 (2003). PubMed ID: 14506720

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:ITGB1Type of molecule:Adhesion Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. X. Du, T. C. Saido, S. Tsubuki, et al., J. Biol. Chem. 270, 26146 (1995). PubMed ID: 7592818

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:MARCKSType of molecule:ActinBundling Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. S. Dulong, S. Goudenege, K. Vuillier-Devillers, et al., Biochem. J. 382, 1015 (2004). PubMed ID: 15239673

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. R. Yamaguchi, M. Maki, M. Hatanaka, et al., FEBS. Lett. 356, 114 (1995). PubMed ID: 7988702

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:ARHGEF6Type of molecule:GEF Location:FAC
Type of interaction:Binding Effect:0
References:
1. G. Rosenberger, A. Gal, K. Kutsche, J. Biol. Chem. 280, 6879 (2005). PubMed ID: 15611136

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. J. V. Frangioni, A. Oda, M. Smith, et al., EMBO. J. 12, 4843 (1993). PubMed ID: 8223493

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:RHOAType of molecule:GTPase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. S. Kulkarni, D. E. Goll, J. E. Fox, J. Biol. Chem. 277, 24435 (2002). PubMed ID: 11964413

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. H. Falet, S. Pain, F. Rendu, Biochem. Biophys. Res. Commun. 252, 51 (1998). PubMed ID: 9813145

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:SRCType of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. A. Oda, B. J. Druker, H. Ariyoshi, et al., J. Biol. Chem. 268, 12603 (1993). PubMed ID: 7685344

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:TLN1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. S. J. Franco, M. A. Rodgers, B. J. Perrin, et al., Nat. Cell. Biol. 6, 977 (2004). PubMed ID: 15448700

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:TNS1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. H. Chen, A. Ishii, W. K. Wong, et al., Biochem. J. 351, 403 (2001). PubMed ID: 11023826

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:VCLType of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. K. Serrano, D. V. Devine, Cell. Motil. Cytoskeleton. 58, 242 (2004). PubMed ID: 15236355

Source:CAPN1Type of molecule:CysProtease Location:FACA
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. A. Oda, K. Ozaki, B. J. Druker, et al., Blood. 88, 1330 (1996). PubMed ID: 8695851

Source:MAPK1Type of molecule:SerThrKinase Location:FACA
Target:CAPN1Type of molecule:CysProtease Location:FACA
Type of interaction:Activation Effect:+
References:
1. A. Glading, R. J. Bodnar, I. J. Reynolds, et al., Mol. Cell. Biol. 24, 2499 (2004). PubMed ID: 14993287

Source:PRKACAType of molecule:SerThrKinase Location:FACA
Target:CAPN1Type of molecule:CysProtease Location:FACA
Type of interaction:Activation Effect:+
References:
1. H. Shiraha, A. Glading, J. Chou, et al., Mol. Cell. Biol. 22, 2716 (2002). PubMed ID: 11909964

Source:PRKCAType of molecule:SerThrKinase Location:FAC
Target:CAPN1Type of molecule:CysProtease Location:FACA
Type of interaction:Activation Effect:+
References:
1. B. J. Perrin, A. Huttenlocher, Int. J. Biochem. Cell. Biol. 34, 722 (2002). PubMed ID: 11950589

Source:CalciumType of molecule:Messenger Location:FACA
Target:CAPN1Type of molecule:CysProtease Location:FACA
Type of interaction:Activation Effect:+
References:
1. T. Murachi, Biochem. Soc. Symp. 49, 149 (1986). PubMed ID: 6100833