Focal Adhesion Network Components

BCAR1

Swiss-Prot Human Accession Code: P56945
List of interactions:

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. B. J. Mayer, H. Hirai, R. Sakai, Curr. Biol. 5, 296 (1995). PubMed ID: 7780740

Source:JUBType of molecule:Cytoskeletal Location:FAC
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. J. Pratt, H. Epple, M. Ward, et al., J. Cell. Biol. 168, 813 (2005). PubMed ID: 15728191

Source:BCAR3Type of molecule:GEF Location:FACA
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. T. Gotoh, D. Cai, X. Tian, et al., J. Biol. Chem. 275, 30118 (2000). PubMed ID: 10896938

Source:RAPGEF1Type of molecule:GEF Location:FACA
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. K. H. Kirsch, M. M. Georgescu, H. Hanafusa, J. Biol. Chem. 273, 25673 (1998). PubMed ID: 9748234

Source:BCAR1Type of molecule:Cytoskeletal Location:FAC
Target:CRKType of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. Sakai, A. Iwamatsu, N. Hirano, et al., EMBO. J. 13, 3748 (1994). PubMed ID: 8070403

Source:BCAR1Type of molecule:Cytoskeletal Location:FAC
Target:CRKLType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. Salgia, E. Pisick, M. Sattler, et al., J. Biol. Chem. 271, 25198 (1996). PubMed ID: 8810278

Source:BCAR1Type of molecule:Cytoskeletal Location:FAC
Target:PTK2Type of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. B. Kovacic-Milivojevic, F. Roediger, E. A. Almeida, et al., Mol. Biol. Cell. 12, 2290 (2001). PubMed ID: 11514617

Source:BCAR1Type of molecule:Cytoskeletal Location:FAC
Target:MAPK8IP3Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. T. Takino, M. Nakada, H. Miyamori, et al., J. Biol. Chem. 280, 37772 (2005). PubMed ID: 16141199

Source:BCAR1Type of molecule:Cytoskeletal Location:FAC
Target:LYNType of molecule:TyrKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. W. Qiu, R. R. Cobb, W. Scholz, J. Leukoc. Biol. 63, 631 (1998). PubMed ID: 9581808

Source:BCAR1Type of molecule:Cytoskeletal Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. A. Astier, H. Avraham, S. N. Manie, et al., J. Biol. Chem. 272, 228 (1997). PubMed ID: 8995252

Source:BCAR1Type of molecule:Cytoskeletal Location:FAC
Target:TRIP6Type of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. J. Yi, S. Kloeker, C. C. Jensen, et al., J. Biol. Chem. 277, 9580 (2002). PubMed ID: 11782456

Source:BCAR1Type of molecule:Cytoskeletal Location:FAC
Target:PIK3CAType of molecule:PtdInsKinase Location:FACA
Type of interaction:Binding Effect:0
References:
1. E. Li, D. G. Stupack, S. L. Brown, et al., J. Biol. Chem. 275, 14729 (2000). PubMed ID: 10799562

Source:FYNType of molecule:TyrKinase Location:FACA
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. N. Manie, A. Astier, N. Haghayeghi, et al., J. Biol. Chem. 272, 15636 (1997). PubMed ID: 9188452

Source:NEDD9Type of molecule:Cytoskeletal Location:FAC
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. F. Law, J. Estojak, B. Wang, et al., Mol. Cell. Biol. 16, 3327 (1996). PubMed ID: 8668148

Source:PTPRFType of molecule:TyrPhosphatase Location:FAC
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. X. Wang, L. P. Weng, Q. Yu, Oncogene. 19, 2346 (2000). PubMed ID: 10822386

Source:PPP2CAType of molecule:SerThrPhosphatase Location:FAC
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. N. Yokoyama, W. T. Miller, Oncogene. 20, 6057 (2001). PubMed ID: 11593413

Source:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. F. Liu, D. E. Hill, J. Chernoff, J. Biol. Chem. 271, 31290 (1997). PubMed ID: 8940134

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. A. J. Garton, A. J. Flint, N. K. Tonks, Mol. Cell. Biol. 16, 6408 (1996). PubMed ID: 8887669

Source:PTPRAType of molecule:TyrPhosphatase Location:FAC
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. Q. Hao, S. A. Rutherford, B. Low, et al., Free. Radic. Biol. Med. 41, 302 (2006). PubMed ID: 16814111

Source:PTPRHType of molecule:TyrPhosphatase Location:FACA
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. T. Noguchi, M. Tsuda, H. Takeda, et al., J. Biol. Chem. 276, 15216 (2001). PubMed ID: 11278335

Source:SRCType of molecule:TyrKinase Location:FAC
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. G. S. Goldberg, D. B. Alexander, P. Pellicena, et al., J. Biol. Chem. 278, 46533 (2003). PubMed ID: 12972425