Focal Adhesion Network Components

AKT1

Swiss-Prot Human Accession Code: P31749
List of interactions:

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:ITGB1Type of molecule:Adhesion Location:FAC
Type of interaction:Activation Effect:+
References:
1. R. I. Kirk, M. R. Sanderson, K. M. Lerea, J. Biol. Chem. 275, 30901 (2000). PubMed ID: 10896934

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:IRS1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. K. Paz, Y. F. Liu, H. Shorer, et al., J. Biol. Chem. 274, 28816 (1999). PubMed ID: 10497255

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. G. L. Zhou, Y. Zhuo, C. C. King, et al., Mol. Cell. Biol. 23, 8058 (2003). PubMed ID: 14585966

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:PRKCAType of molecule:SerThrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. B. Bauer, N. Krumbock, F. Fresser, et al., J. Biol. Chem. 276, 31627 (2001). PubMed ID: 11410591

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:PTPN1Type of molecule:TyrPhosphatase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. L. V. Ravichandran, H. Chen, Y. Li, et al., Mol. Endocrinol. 15, 1768 (2001). PubMed ID: 11579209

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:RAC1Type of molecule:GTPase Location:FACA
Type of interaction:Activation Effect:+
References:
1. T. Kwon, D. Y. Kwon, J. Chun, et al., J. Biol. Chem. 275, 423 (2000). PubMed ID: 10617634

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:ILKType of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. M. Delcommenne, C. Tan, V. Gray, et al., Proc. Natl. Acad. Sci. U. S. A. 95, 11211 (1998). PubMed ID: 9736715

Source:AKT1Type of molecule:SerThrKinase Location:FACA
Target:FLNAType of molecule:ActinBinding Location:FAC
Type of interaction:Activation Effect:+
References:
1. J. T. Murray, D. G. Campbell, M. Peggie, et al., Biochem. J. 384, 489 (2004). PubMed ID: 15461588

Source:ILKType of molecule:SerThrKinase Location:FAC
Target:AKT1Type of molecule:SerThrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. M. Delcommenne, C. Tan, V. Gray, et al., Proc. Natl. Acad. Sci. U. S. A. 95, 11211 (1998). PubMed ID: 9736715

Source:PDPK1Type of molecule:SerThrKinase Location:FAC
Target:AKT1Type of molecule:SerThrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. F. Rintelen, H. Stocker, G. Thomas, et al., Proc. Natl. Acad. Sci. U. S. A. 98, 15020 (2001). PubMed ID: 11752451

Source:PIP3Type of molecule:Lipid Location:FACA
Target:AKT1Type of molecule:SerThrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. S. A. Didichenko, B. Tilton, B. A. Hemmings, et al., Curr. Biol. 6, 1271 (1997). PubMed ID: 8939574

Source:PPP2CAType of molecule:SerThrPhosphatase Location:FAC
Target:AKT1Type of molecule:SerThrKinase Location:FACA
Type of interaction:Inhibition Effect:_
References:
1. R. Pankov, E. Cukierman, K. Clark, et al., J. Biol. Chem. 278, 18671 (2003). PubMed ID: 12637511

Source:SRCType of molecule:TyrKinase Location:FAC
Target:AKT1Type of molecule:SerThrKinase Location:FACA
Type of interaction:Activation Effect:+
References:
1. T. Jiang, Y. Qiu, J. Biol. Chem. 278, 15789 (2003). PubMed ID: 12600984