Focal Adhesion Network Components

ABL1

Swiss-Prot Human Accession Code: P00519
List of interactions:

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:ABI1Type of molecule:Adapter Location:FACA
Type of interaction:Activation Effect:+
References:
1. P. D. Fan, F. Cong, S. P. Goff, Cancer. Res. 63, 873 (2003). PubMed ID: 12591740

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:SORBS2Type of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. B. Wang, E. A. Golemis, G. D. Kruh, J. Biol. Chem. 272, 17542 (1997). PubMed ID: 9211900

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:BCAR1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. B. J. Mayer, H. Hirai, R. Sakai, Curr. Biol. 5, 296 (1995). PubMed ID: 7780740

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:CAV1Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. A. R. Sanguinetti, C. C. Mastick, Cell. Signal. 15, 289 (2003). PubMed ID: 12531427

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:CRKType of molecule:Cytoskeletal Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. Ren, Z. S. Ye, D. Baltimore, Genes. Dev. 8, 783 (1994). PubMed ID: 7926767

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:CRKLType of molecule:Adapter Location:FAC
Type of interaction:Binding Effect:0
References:
1. R. Salgia, N. Uemura, K. Okuda, et al., J. Biol. Chem. 270, 29145 (1996). PubMed ID: 7493940

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:NEDD9Type of molecule:Cytoskeletal Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. F. Law, J. Estojak, B. Wang, et al., Mol. Cell. Biol. 16, 3327 (1996). PubMed ID: 8668148

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:LASP1Type of molecule:ActinBinding Location:FAC
Type of interaction:Activation Effect:+
References:
1. Y. H. Lin, Z. Y. Park, D. Lin, et al., J. Cell. Biol. 165, 421 (2004). PubMed ID: 15138294

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:RASA1Type of molecule:GAP Location:FAC
Type of interaction:Binding Effect:0
References:
1. T. Skorski, P. Kanakaraj, D. H. Ku, et al., J. Exp. Med. 179, 1855 (1994). PubMed ID: 8195713

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:PAK1Type of molecule:SerThrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. J. Roig, P. T. Tuazon, P. A. Zipfel, et al., Proc. Natl. Acad. Sci. U. S. A. 97, 14346 (2001). PubMed ID: 11121037

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:PXNType of molecule:Adapter Location:FAC
Type of interaction:Activation Effect:+
References:
1. J. M. Lewis, M. A. Schwartz, J. Biol. Chem. 273, 14225 (1998). PubMed ID: 9603926

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:SORBS1Type of molecule:Adapter Location:FACA
Type of interaction:Binding Effect:0
References:
1. W. H. Lin, C. J. Huang, M. W. Liu, et al., Genomics. 74, 12 (2001). PubMed ID: 11374898

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:PTK2BType of molecule:TyrKinase Location:FAC
Type of interaction:Binding Effect:0
References:
1. S. Zrihan-Licht, S. Avraham, S. Jiang, et al., Int. J. Oncol. 24, 153 (2003). PubMed ID: 14654952

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:INPPL1Type of molecule:PtdInsPhosphatase Location:FAC
Type of interaction:Binding Effect:0
References:
1. D. Wisniewski, A. Strife, S. Swendeman, et al., Blood. 93, 2707 (1999). PubMed ID: 10194451

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:PTPN6Type of molecule:TyrPhosphatase Location:FAC
Type of interaction:Activation Effect:+
References:
1. S. Kharbanda, A. Bharti, D. Pei, et al., Proc. Natl. Acad. Sci. U. S. A. 93, 6898 (1996). PubMed ID: 8692915

Source:ABL1Type of molecule:TyrKinase Location:FAC
Target:CBLType of molecule:E3ligase Location:FACA
Type of interaction:Activation Effect:+
References:
1. C. E. Andoniou, C. B. Thien, W. Y. Langdon, EMBO. J. 13, 4515 (1994). PubMed ID: 7925293

Source:ACTBType of molecule:Cytoskeletal Location:FAC
Target:ABL1Type of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. et al., J. Cell. Biol. 124, 325 (1994). PubMed ID: 8294516

Source:CBLType of molecule:E3ligase Location:FACA
Target:ABL1Type of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. P. Soubeyran, A. Barac, I. Szymkiewicz, et al., Biochem. J. 370, 29 (2003). PubMed ID: 12475393

Source:PAK1Type of molecule:SerThrKinase Location:FAC
Target:ABL1Type of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. J. Roig, P. T. Tuazon, P. A. Zipfel, et al., Proc. Natl. Acad. Sci. U. S. A. 97, 14346 (2001). PubMed ID: 11121037

Source:PTPN12Type of molecule:TyrPhosphatase Location:FAC
Target:ABL1Type of molecule:TyrKinase Location:FAC
Type of interaction:Inhibition Effect:_
References:
1. PubMed ID: 11163214

Source:SRCType of molecule:TyrKinase Location:FAC
Target:ABL1Type of molecule:TyrKinase Location:FAC
Type of interaction:Activation Effect:+
References:
1. R. Plattner, L. Kadlec, K. A. DeMali, et al., Genes. Dev. 13, 2400 (1999). PubMed ID: 10500097