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Project Description

This web site presents a collaborative project between the Geiger Laboratory, Weizmann Institute of Science and the Iyengar Laboratory, Mount Sinai School of Medicine. This project is part of the activities of the Nanotechnology Center for Mechanics in Regenerative Medicine headed by Michael Sheetz from Columbia University and was supported in part by the National Institute of Health through the NIH Roadmap for Medical Research (PN2 EY016586). Other support includes GM-54508 from the NIH and Advanced Research Center Grant NYSTAR from New York State to RI.

A comprehensive in-silico biochemical network has been developed from biomedical literature. The network is made of known interactions and cellular components composing the focal adhesion complex in mammalian cells. This site provides a reference and supporting materials to the analysis article: "Functional atlas of the integrin adhesome" by Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Nat Cell Biol. 2007 Aug;9(8):858-67 PubMed ID: 17671451. Our intent is to provide for the research community a resource for exploring interactions, components and network motifs found in focal adhesion complexes for their further analysis towards enhanced understanding of focal adhesion complex formation, regulation and dynamics.
Currently, the network includes 156 components and 690 interactions with an average of 8.66 interactions per component, a clustering coefficient of 0.24, and characteristic average path-length of 2.6. This web-site provides dynamically linked web-pages for browsing and exploring focal adhesion network components, interactions and network motifs as well as providing access to download the interaction dataset in different formats.